Synonym
KC 399; KC399; KC-399
IUPAC/Chemical Name
2H-1-Benzopyran-4-carbothioamide, N-(2-cyanoethyl)-2,2-bis(fluoromethyl)-6-nitro-
InChi Key
LKUDLWNQCZSCQW-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H13F2N3O3S/c16-8-15(9-17)7-12(14(24)19-5-1-4-18)11-6-10(20(21)22)2-3-13(11)23-15/h2-3,6-7H,1,5,8-9H2,(H,19,24)
SMILES Code
S=C(C1=CC(CF)(CF)OC2=CC=C([N+]([O-])=O)C=C12)NCCC#N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
353.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kamei K, Nabata H, Kuriyama H. Effects of KC 399, a novel ATP-sensitive K+ channel opener, on electrical and mechanical responses in dog tracheal smooth muscle. J Pharmacol Exp Ther. 1994 Jan;268(1):319-27. PMID: 8301573.
2: Tamura K, Suzuki Y, Yoshida S, Nabata H. Action of KC-399, a newly synthesized potassium channel opener, on mechanical activity and 86Rb efflux in rat aorta. J Cardiovasc Pharmacol. 1994 Feb;23(2):220-6. PMID: 7511750.
3: Imagawa J, Kamei K, Yoshida S, Sugo I, Koga T, Nabata H. In vivo bronchodilator action of a novel K+ channel opener, KC 399, in the guinea pig. J Pharmacol Exp Ther. 1994 Apr;269(1):1-6. PMID: 8169816.
4: Imagawa J, Yoshida S, Koga T, Kamei K, Nabata H. The effect of a novel benzopyran derivative, KC 399, on the isolated guinea-pig trachealis and human bronchi. Gen Pharmacol. 1993 Nov;24(6):1505-12. doi: 10.1016/0306-3623(93)90444-3. PMID: 8112528.
5: Kamei K, Nabata H, Kuriyama H, Watanabe Y, Itoh T. Effect of KC399, a newly synthesized K+ channel opener, on acetylcholine-induced electrical and mechanical activities in rabbit tracheal smooth muscle. Br J Pharmacol. 1995 Aug;115(8):1493-501. doi: 10.1111/j.1476-5381.1995.tb16642.x. PMID: 8564210; PMCID: PMC1908865.
