MedKoo Cat#: 592296 | Name: Pam 1392

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pam 1392 is a chemotherapeutic agent.

Chemical Structure

Pam 1392
Pam 1392
CAS#13794-65-5

Theoretical Analysis

MedKoo Cat#: 592296

Name: Pam 1392

CAS#: 13794-65-5

Chemical Formula: C15H15CL2N5

Exact Mass: 333.0548

Molecular Weight: 334.20

Elemental Analysis: C, 53.91; H, 3.92; Cl, 21.21; N, 20.96

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Synonym
Pam 1392; AI3-52841; AI3 52841; AI352841
IUPAC/Chemical Name
2,4,6-Quinazolinetriamine, N6-((3,4-dichlorophenyl)methyl)-
InChi Key
LTSQDQVTNREIAO-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H13Cl2N5/c16-11-3-1-8(5-12(11)17)7-20-9-2-4-13-10(6-9)14(18)22-15(19)21-13/h1-6,20H,7H2,(H4,18,19,21,22)
SMILES Code
NC1=NC(N)=C2C=C(NCC3=CC=C(Cl)C(Cl)=C3)C=CC2=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 334.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Matsui T, Tasaki M, Yoshioka T, Motoki Y, Tsuneoka H, Nojima J. Temperature- and time-dependent changes in TLR2-activated microglial NF-κB activity and concentrations of inflammatory and anti-inflammatory factors. Intensive Care Med. 2012 Aug;38(8):1392-9. doi: 10.1007/s00134-012-2591-3. Epub 2012 Jun 1. PubMed PMID: 22653369. 2: Shepard CC. Further experience with the kinetic method for the study of drugs against Mycobacterium leprae in mice. Activities of DDS, DFD, ethionamide, capreomycin and PAM 1392. Int J Lepr Other Mycobact Dis. 1969 Oct-Dec;37(4):389-97. PubMed PMID: 4918202. 3: Thompson PE, Bayles A, Olszewski B. PAM 1392 (2,4-diamino-6-(3,4-dichlorobenzylamino) quinazoline) as a chemotherapeutic agent: Plasmodium berghei, P. cynomolgi, P. Exp Parasitol. 1969 Aug;25(1):32-49. PubMed PMID: 4983051.