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MedKoo Cat#: 535066 | Name: GM 1489

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GM 1489 is a matrix metalloproteinase inhibitor.

Chemical Structure

GM 1489
GM 1489
CAS#170905-75-6

Theoretical Analysis

MedKoo Cat#: 535066

Name: GM 1489

CAS#: 170905-75-6

Chemical Formula: C27H33N3O5

Exact Mass: 479.2420

Molecular Weight: 479.58

Elemental Analysis: C, 67.62; H, 6.94; N, 8.76; O, 16.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GM 1489; GM-1489; GM1489
IUPAC/Chemical Name
N-(2-Carboxymethyl-4-methylpentanoyl)tryptophan 1-phenethylamide
InChi Key
QQSPFAXBRYURLA-AKRCKQFNSA-N
InChi Code
InChI=1S/C27H33N3O5/c1-18(2)14-20(16-25(31)32)26(33)29-23(27(34)35)15-21-17-30(24-11-7-6-10-22(21)24)28-13-12-19-8-4-3-5-9-19/h3-11,17-18,20,23,28H,12-16H2,1-2H3,(H,29,33)(H,31,32)(H,34,35)/t20?,23-/m0/s1
SMILES Code
O=C(O)[C@H](CC1=CN(NCCC2=CC=CC=C2)C3=C1C=CC=C3)NC(C(CC(O)=O)CC(C)C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 479.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Matin A, Stins M, Kim KS, Khan NA. Balamuthia mandrillaris exhibits metalloprotease activities. FEMS Immunol Med Microbiol. 2006 Jun;47(1):83-91. doi: 10.1111/j.1574-695X.2006.00065.x. PMID: 16706791. 2: Holleran WM, Galardy RE, Gao WN, Levy D, Tang PC, Elias PM. Matrix metalloproteinase inhibitors reduce phorbol ester-induced cutaneous inflammation and hyperplasia. Arch Dermatol Res. 1997 Feb;289(3):138-44. doi: 10.1007/s004030050169. PMID: 9128761. 3: Kocer SS, Walker SG, Zerler B, Golub LM, Simon SR. Metalloproteinase inhibitors, nonantimicrobial chemically modified tetracyclines, and ilomastat block Bacillus anthracis lethal factor activity in viable cells. Infect Immun. 2005 Nov;73(11):7548-57. doi: 10.1128/IAI.73.11.7548-7557.2005. PMID: 16239558; PMCID: PMC1273843. 4: Tupper JT, Tedeschi H. Mitochondrial membrane potentials measured with microelectrodes: probable ionic basis. Science. 1969 Dec 19;166(3912):1539-40. doi: 10.1126/science.166.3912.1539. PMID: 17655056.