MedKoo Cat#: 462363 | Name: AZD3458
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZD3458 is a potent and remarkably selective PI3Kγ inhibitor for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ.

Chemical Structure

AZD3458
AZD3458
CAS#2132961-46-5

Theoretical Analysis

MedKoo Cat#: 462363

Name: AZD3458

CAS#: 2132961-46-5

Chemical Formula: C20H23N3O4S2

Exact Mass: 433.1130

Molecular Weight: 433.54

Elemental Analysis: C, 55.41; H, 5.35; N, 9.69; O, 14.76; S, 14.79

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 600.00 2 Weeks
25mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
AZD3458; AZD-3458; AZD 3458
IUPAC/Chemical Name
(S)-N-(5-(2-(1-cyclopropylethyl)-7-(methylsulfonyl)-1-oxoisoindolin-5-yl)-4-methylthiazol-2-yl)acetamide
InChi Key
PAQUFWFUOVDUIO-NSHDSACASA-N
InChi Code
InChI=1S/C20H23N3O4S2/c1-10-18(28-20(21-10)22-12(3)24)14-7-15-9-23(11(2)13-5-6-13)19(25)17(15)16(8-14)29(4,26)27/h7-8,11,13H,5-6,9H2,1-4H3,(H,21,22,24)/t11-/m0/s1
SMILES Code
O=C1N([C@@H](C)C2CC2)CC3=CC(C4=C(C)N=C(NC(C)=O)S4)=CC(S(=O)(C)=O)=C31
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 433.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pemberton N, Mogemark M, Arlbrandt S, et al. Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors. J Med Chem. 2018;61(12):5435-5441. doi:10.1021/acs.jmedchem.8b00447