MedKoo Cat#: 462349 | Name: CMLD010509

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CMLD010509 is a highly specific inhibitor of the oncogenic translation program supporting multiple myeloma (MM)-including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1.

Chemical Structure

CMLD010509
CMLD010509
CAS#256497-58-2

Theoretical Analysis

MedKoo Cat#: 462349

Name: CMLD010509

CAS#: 256497-58-2

Chemical Formula: C27H26BrNO7

Exact Mass: 555.0893

Molecular Weight: 556.41

Elemental Analysis: C, 58.28; H, 4.71; Br, 14.36; N, 2.52; O, 20.13

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Synonym
CMLD010509; CMLD-010509; CMLD 010509; SDS-1-021; SDS 1-021; SDS 1-021
IUPAC/Chemical Name
(1R,2R,3S,3aR,8bS)-3a-(4-bromophenyl)-1,8b-dihydroxy-N,6,8-trimethoxy-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxamide
InChi Key
VVCMGKRXILWBQB-PXIJUOARSA-N
InChi Code
InChI=1S/C27H26BrNO7/c1-33-18-13-19(34-2)23-20(14-18)36-27(16-9-11-17(28)12-10-16)22(15-7-5-4-6-8-15)21(25(31)29-35-3)24(30)26(23,27)32/h4-14,21-22,24,30,32H,1-3H3,(H,29,31)/t21-,22-,24-,26+,27+/m1/s1
SMILES Code
O=C(NOC)[C@@H]([C@H]([C@@]1([C@]2(OC3=CC(OC)=CC(OC)=C13)C4=CC=C(C=C4)Br)O)O)[C@H]2C5=CC=CC=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 556.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Manier S, Huynh D, Shen YJ, et al. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med. 2017;9(389):eaal2668. doi:10.1126/scitranslmed.aal2668