IUPAC/Chemical Name
Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-iodo-2-methoxy-, (R)-
InChi Key
JHMTYLJMPBFCTD-GFCCVEGCSA-N
InChi Code
InChI=1S/C15H21IN2O2/c1-3-18-8-4-5-12(18)10-17-15(19)13-9-11(16)6-7-14(13)20-2/h6-7,9,12H,3-5,8,10H2,1-2H3,(H,17,19)/t12-/m1/s1
SMILES Code
O=C(NC[C@@H]1N(CC)CCC1)C2=CC(I)=CC=C2OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
388.25
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: de Paulis T. The discovery of epidepride and its analogs as high-affinity radioligands for imaging extrastriatal dopamine D(2) receptors in human brain. Curr Pharm Des. 2003;9(8):673-96. doi: 10.2174/1381612033391135. PMID: 12570798.
2: Janowsky A, De Paulis T, Clanton JA, Smith HE, Ebert MH, Kessler RM. [125I]iodopride: a specific high affinity radioligand for labelling striatal dopamine D-2 receptors. Eur J Pharmacol. 1988 May 20;150(1-2):203-5. doi: 10.1016/0014-2999(88)90772-8. PMID: 3402540.
3: Kessler RM, Ansari MS, de Paulis T, Schmidt DE, Clanton JA, Smith HE, Manning RG, Gillespie D, Ebert MH. High affinity dopamine D2 receptor radioligands. 1. Regional rat brain distribution of iodinated benzamides. J Nucl Med. 1991 Aug;32(8):1593-600. PMID: 1831229.
4: Maimone S, Filomia R, Saitta C, Raimondo G, Squadrito G. Case Report: Atrial Fibrillation After Intravenous Administration of Iodinated Contrast Medium in a Patient With Hepatocellular Carcinoma. Medicine (Baltimore). 2015 Sep;94(35):e1406. doi: 10.1097/MD.0000000000001406. PMID: 26334896; PMCID: PMC4616515.
5: de Paulis T, Janowsky A, Kessler RM, Clanton JA, Smith HE. (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-[125I]iodo- 2-methoxybenzamide hydrochloride, a new selective radioligand for dopamine D-2 receptors. J Med Chem. 1988 Oct;31(10):2027-33. doi: 10.1021/jm00118a031. PMID: 3172140.
