HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.
MedKoo Cat#: 462306
Name: HKI-357
CAS#: 848133-17-5 (free base)
Chemical Formula: C31H29ClFN5O3
Exact Mass: 573.1943
Molecular Weight: 574.05
Elemental Analysis: C, 64.86; H, 5.09; Cl, 6.18; F, 3.31; N, 12.20; O, 8.36
The following data is based on the product molecular weight 574.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
