INH1 | CAS#313553-47-8

MedKoo Cat#: 559006 | Name: INH1

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

INH1 is an inhibitor of the interaction between the oncogene high expression in cancer 1 (Hec1) and its regulator, the serine/threonine kinase Nek2.

Chemical Structure

INH1

CAS#313553-47-8

Theoretical Analysis

MedKoo Cat#: 559006

Name: INH1

CAS#: 313553-47-8

Chemical Formula: C18H16N2OS

Exact Mass: 308.0983

Molecular Weight: 308.40

Elemental Analysis: C, 70.10; H, 5.23; N, 9.08; O, 5.19; S, 10.40

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 250.00	2 Weeks
50mg	USD 650.00	2 Weeks

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Related CAS #

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Synonym

INH1, IBT 13131, IBT13131, IBT-13131

IUPAC/Chemical Name

N-[4-(2,4-dimethylphenyl)-2-thiazolyl]-benzamide

InChi Key

JPMOKRWIYQGMJL-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H16N2OS/c1-12-8-9-15(13(2)10-12)16-11-22-18(19-16)20-17(21)14-6-4-3-5-7-14/h3-11H,1-2H3,(H,19,20,21)

SMILES Code

O=C(C1=CC=CC=C1)NC2=NC(C3=CC=C(C)C=C3C)=CS2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

INH1 specifically disrupts the Hec1/Nek2 interaction via direct Hec1 binding. INH1 shows promising cancer inhibition activity both in vitro and in vivo.

In vitro activity:

Results obtained from independent colonogenic survival assays further confirmed the cell killing activity of INH1 towards at least two breast cancer lines (MCF7 and MDA-MB-468) (Fig. 4B), as well as the cervical adenocarcinoma line HeLa and the colon cancer line HCT116 (data not shown). Taken together, these data suggest that INH1 inhibits the proliferation of cancer cells in culture. Reference: Cancer Res. 2008 Oct 15;68(20):8393-9. https://pubmed.ncbi.nlm.nih.gov/18922912/

In vivo activity:

Remarkably, at both 50 and 100 mg/kg doses, INH1 treated mice showed significant tumor growth retardation (Fig. 6A). The side effects were minimal, if any, as indicated by the comparable body weight (Fig. 6B) and the autopsy (data not shown) between different groups. This study indicates that INH1 is effective in inhibiting tumor growth in animals. Reference: Cancer Res. 2008 Oct 15;68(20):8393-9. https://pubmed.ncbi.nlm.nih.gov/18922912/

	Solvent	mg/mL	mM
Solubility
	DMSO	63.7	206.44
	DMSO:PBS (pH 7.2) (1:2)	0.3	0.97
	Ethanol	35.5	115.11

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 308.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Wu G, Qiu XL, Zhou L, Zhu J, Chamberlin R, Lau J, Chen PL, Lee WH. Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res. 2008 Oct 15;68(20):8393-9. doi: 10.1158/0008-5472.CAN-08-1915. PMID: 18922912; PMCID: PMC2709694.

In vitro protocol:

In vivo protocol:

1. Wu, G., Qiu, X.-L., Zhou, L., et al. Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res. 68(20), 8393-8399 (2008). 2. Zheng, S., Zhong, Q., Jiang, Q., et al. Discovery of a series of thiazole derivatives as novel inhibitors of metastatic cancer cell migration and invasion. ACS Med. Chem. Lett. 4(2), 191-196 (2013).