Synonym
TCO-PEG3-maleimide; trans-Cyclooctene-maleimide
IUPAC/Chemical Name
(E)-cyclooct-4-en-1-yl (17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-15-oxo-4,7,10-trioxa-14-azaheptadecyl)carbamate
InChi Key
BJZRPWAVCDJCTC-OWOJBTEDSA-N
InChi Code
InChI=1S/C26H41N3O8/c30-23(12-15-29-24(31)10-11-25(29)32)27-13-6-16-34-18-20-36-21-19-35-17-7-14-28-26(33)37-22-8-4-2-1-3-5-9-22/h1-2,10-11,22H,3-9,12-21H2,(H,27,30)(H,28,33)/b2-1+
SMILES Code
O=C(OC1CCC/C=C/CC1)NCCCOCCOCCOCCCNC(CCN2C(C=CC2=O)=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
523.63
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Allo B, Lou X, Bouzekri A, Ornatsky O. Clickable and High-Sensitivity Metal-Containing Tags for Mass Cytometry. Bioconjug Chem. 2018 Jun 20;29(6):2028-2038. doi: 10.1021/acs.bioconjchem.8b00239. Epub 2018 May 17. PMID: 29733585.
2. Platzer R, Rossboth BK, Schneider MC, Sevcsik E, Baumgart F, Stockinger H, Schütz GJ, Huppa JB, Brameshuber M. Unscrambling fluorophore blinking for comprehensive cluster detection via photoactivated localization microscopy. Nat Commun. 2020 Oct 5;11(1):4993. doi: 10.1038/s41467-020-18726-9. PMID: 33020470; PMCID: PMC7536177.
3: Bibi, I., Mushtaq, S., Lee, K. C., Park, J. A., & Kim, J. Y. (2024). From molecules to medicine: thiol selective bioconjugation in synthesis of diagnostic and therapeutic radiopharmaceuticals. Theranostics, 14(6), 2396.
4: Xu, L., Raabe, M., Zegota, M. M., Nogueira, J. C., Chudasama, V., Kuan, S. L., & Weil, T. (2020). Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation. Organic & biomolecular chemistry, 18(6), 1140-1147.
