Synonym
HB 180; HB-180; HB180
IUPAC/Chemical Name
N-(((4-Methylcyclohexyl)amino)carbonyl)-4-(2-(((methyl-2-pyridylamino)carbonyl)amino)ethyl)benzenesulphonamide
InChi Key
UIXYQZIHFQKFOZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H31N5O4S/c1-17-6-10-19(11-7-17)26-22(29)27-33(31,32)20-12-8-18(9-13-20)14-16-25-23(30)28(2)21-5-3-4-15-24-21/h3-5,8-9,12-13,15,17,19H,6-7,10-11,14,16H2,1-2H3,(H,25,30)(H2,26,27,29)
SMILES Code
O=S(C1=CC=C(CCNC(N(C)C2=NC=CC=C2)=O)C=C1)(NC(NC3CCC(C)CC3)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
473.59
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Antezana AM, Antezana G, Aparicio O, Noriega I, Velarde FL, Richalet JP. Pulmonary hypertension in high-altitude chronic hypoxia: response to nifedipine. Eur Respir J. 1998 Nov;12(5):1181-5. doi: 10.1183/09031936.98.12051181. PMID: 9864018.
2: Feng B, Xu WH, Gao YQ, Liu FY, Li P, Zheng SJ, Gai LY, Zhang G. Intermittent Oxygen Inhalation with Proper Frequency Improves Overall Health Conditions and Alleviates Symptoms in a Population at High Risk of Chronic Mountain Sickness with Severe Symptoms. Chin Med J (Engl). 2016 Jun 5;129(11):1322-9. doi: 10.4103/0366-6999.182831. PMID: 27231170; PMCID: PMC4894043.
3: Gastpar H, Weissgerber PW, Enzmann F, Zoltobrocki M. The inhibition of cancer cell stickiness, a model for investigation of platelet aggregation inhibitors in vivo. Effect of the sulfonyl urea derivatives, glibenclamide, gliclazide, and HB180, as well as the carboxylic acid derivative, meglitinide. Res Exp Med (Berl). 1982;180(1):75-84. doi: 10.1007/BF01852234. PMID: 6805052.