E7766 | 2242635-02-3 | STING agonist

MedKoo Cat#: 207131 | Name: E7766

Description:

WARNING: This product is for research use only, not for human or veterinary use.

E7766 is a STING agonist. E7766 shows superior in vitro activity against all the major human STING genotypes over reference CDNs, most distinctly in STINGREF. E7766 demonstrated pan-genotypic STING activation, potent anti-cancer activities and excellent chemical and metabolic stability for further development.

Chemical Structure

E7766

CAS#2242635-02-3

Theoretical Analysis

MedKoo Cat#: 207131

Name: E7766

CAS#: 2242635-02-3

Chemical Formula: C24H26F2N10O8P2S2

Exact Mass: 746.0820

Molecular Weight: 746.60

Elemental Analysis: C, 38.61; H, 3.51; F, 5.09; N, 18.76; O, 17.14; P, 8.30; S, 8.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

E7766; E-7766; E 7766;

IUPAC/Chemical Name

(19S,22R,23R,23aR,25R,27aR,29R,210R,210aR,212S,214aR,39S,E)-23,210-difluoro-25,212-dimercapto-23,23a,27a,29,210,210a,214,214a-octahydro-19H,22H,27H,39H-4,9-diaza-1,3(9,6)-dipurina-2(2,9)-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecinacyclononaphan-6-ene 25,212-dioxide

InChi Key

YQSAUMRQALUWNS-VUCARUFASA-N

InChi Code

InChI=1S/C24H26F2N10O8P2S2/c25-13-17-11-5-39-46(38,48)44-18-12(6-40-45(37,47)43-17)42-24(14(18)26)36-10-34-16-20(30-8-32-22(16)36)28-4-2-1-3-27-19-15-21(31-7-29-19)35(9-33-15)23(13)41-11/h1-2,7-14,17-18,23-24H,3-6H2,(H,37,47)(H,38,48)(H,27,29,31)(H,28,30,32)/b2-1+/t11-,12-,13-,14-,17-,18-,23-,24-,45-,46+/m1/s1

SMILES Code

F[C@@H]1[C@H](O2)[C@@H](CO[P@]3(S)=O)O[C@H]1[N@@]4C=NC5=C(NC/C=C/CNC6=C(N=C[N@]7[C@H]8[C@H](F)[C@H](O3)[C@@H](CO[P@@]2(S)=O)O8)C7=NC=N6)N=CN=C54

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 746.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.