GW768505A free base | CAS#501693-25-0 | dual inhibitor of VEGFR2 (KDR) and Tie-2

MedKoo Cat#: 462280 | Name: GW768505A free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2 that has anti-angiogenic activity.

Chemical Structure

GW768505A free base

CAS#501693-25-0

Theoretical Analysis

MedKoo Cat#: 462280

Name: GW768505A free base

CAS#: 501693-25-0

Chemical Formula: C27H19F4N5O3

Exact Mass: 537.1424

Molecular Weight: 537.47

Elemental Analysis: C, 60.34; H, 3.56; F, 14.14; N, 13.03; O, 8.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GW768505A free base; GW 768505A free base; GW-768505A free base

IUPAC/Chemical Name

1-(4-(4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea

InChi Key

FGZIONRFHVNRJB-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H19F4N5O3/c1-38-18-9-4-15(5-10-18)23-21(22-24(32)33-13-34-25(22)39-23)14-2-7-17(8-3-14)35-26(37)36-20-12-16(27(29,30)31)6-11-19(20)28/h2-13H,1H3,(H2,32,33,34)(H2,35,36,37)

SMILES Code

COC(C=C1)=CC=C1C2=C(C3=CC=C(NC(NC4=CC(C(F)(F)F)=CC=C4F)=O)C=C3)C5=C(N)N=CN=C5O2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 537.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Miyazaki Y, Tang J, Maeda Y, et al. Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2. Bioorg Med Chem Lett. 2007;17(6):1773-1778. doi:10.1016/j.bmcl.2006.12.077 2: Elkins JM, Fedele V, Szklarz M, et al. Comprehensive characterization of the Published Kinase Inhibitor Set. Nat Biotechnol. 2016;34(1):95-103. doi:10.1038/nbt.3374