QM31 is a cytoprotective agent and a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint.
MedKoo Cat#: 462270
Name: QM31
CAS#: 937735-00-7
Chemical Formula: C39H38Cl4N4O4
Exact Mass: 766.1647
Molecular Weight: 768.56
Elemental Analysis: C, 60.95; H, 4.98; Cl, 18.45; N, 7.29; O, 8.33
The following data is based on the product molecular weight 768.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
