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MedKoo Cat#: 598151 | Name: Suxamethonium bromide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Suxamethonium bromide is a medication used to cause short-term paralysis as part of general anesthesia.

Chemical Structure

Suxamethonium bromide
Suxamethonium bromide
CAS#55-94-7

Theoretical Analysis

MedKoo Cat#: 598151

Name: Suxamethonium bromide

CAS#: 55-94-7

Chemical Formula: C14H30Br2N2O4

Exact Mass: 0.0000

Molecular Weight: 450.21

Elemental Analysis: C, 37.35; H, 6.72; Br, 35.50; N, 6.22; O, 14.21

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Synonym
Suxamethonium bromide; 370 I.S.; Brevidil M; L.T. 1;
IUPAC/Chemical Name
2,2'-(succinylbis(oxy))bis(N,N,N-trimethylethan-1-aminium) bromide
InChi Key
HKDOIORVQFUBKO-UHFFFAOYSA-L
InChi Code
InChI=1S/C14H30N2O4.2BrH/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
SMILES Code
O=C(OCC[N+](C)(C)C)CCC(OCC[N+](C)(C)C)=O.[Br-].[Br-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 450.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tran DT, Newton EK, Mount VA, Lee JS, Wells GA, Perry JJ. Rocuronium versus succinylcholine for rapid sequence induction intubation. Cochrane Database Syst Rev. 2015 Oct 29;(10):CD002788. doi: 10.1002/14651858.CD002788.pub3. Review. PubMed PMID: 26512948. 2: Arunakirinathan M, Papamichael E, Hacking R. Use of suxamethonium in open eye injuries: a dilemma with explosive consequences. Br J Hosp Med (Lond). 2014 Jul;75(7):418. doi: 10.12968/hmed.2014.75.7.418. PubMed PMID: 25040532. 3: Jiang MZ, Cheng XW, Chu JX. [Progress on suxamethonium chloride analysis]. Fa Yi Xue Za Zhi. 2013 Dec;29(6):451-3. Review. Chinese. PubMed PMID: 24665619. 4: Alvarellos ML, McDonagh EM, Patel S, McLeod HL, Altman RB, Klein TE. PharmGKB summary: succinylcholine pathway, pharmacokinetics/pharmacodynamics. Pharmacogenet Genomics. 2015 Dec;25(12):622-30. doi: 10.1097/FPC.0000000000000170. Review. PubMed PMID: 26398623; PubMed Central PMCID: PMC4631707. 5: Beck W, Kabiche S, Balde IB, Carret S, Fontan JE, Cisternino S, Schlatter J. Stability of suxamethonium in pharmaceutical solution for injection by validated stability-indicating chromatographic method. J Clin Anesth. 2016 Dec;35:551-559. doi: 10.1016/j.jclinane.2016.09.025. Epub 2016 Oct 23. PubMed PMID: 27871592. 6: Ammundsen HB, Sørensen MK, Gätke MR. Succinylcholine resistance. Br J Anaesth. 2015 Dec;115(6):818-21. doi: 10.1093/bja/aev228. Epub 2015 Jul 16. PubMed PMID: 26183168. 7: Lee C. Goodbye suxamethonium! Anaesthesia. 2009 Mar;64 Suppl 1:73-81. doi: 10.1111/j.1365-2044.2008.05873.x. Review. PubMed PMID: 19222434. 8: Rasmussen KG. Recall of paralysis after the seizure with right unilateral ultrabrief technique. J ECT. 2015 Jun;31(2):e26. doi: 10.1097/YCT.0000000000000216. PubMed PMID: 25621544. 9: LEATHERDALE RA, MAYHEW AJ, HAYTON-WILLIAMS DS. Incidence of muscle pain after short-acting relaxants; a comparison between suxamethonium chloride and suxamethonium bromide. Br Med J. 1959 Apr 4;1(5126):904-5. PubMed PMID: 13629159; PubMed Central PMCID: PMC1992897. 10: Eskildsen KZ, Gätke MR. [Danish Cholinesterase Research Unit diagnoses patients with prolonged paralysis after succinylcholine and mivacurium]. Ugeskr Laeger. 2015 Apr 27;177(18):866-8. Review. Danish. PubMed PMID: 26539575. 11: Claudius C, Perner A. [Suxamethonium for intubation of patients in intensive care units?]. Ugeskr Laeger. 2011 Oct 24;173(43):2703. Danish. PubMed PMID: 22027223. 12: Abu-Halaweh SA, Massad IM, Abu-Ali HM, Badran IZ, Barazangi BA, Ramsay MA. Rapid sequence induction and intubation with 1 mg/kg rocuronium bromide in cesarean section, comparison with suxamethonium. Saudi Med J. 2007 Sep;28(9):1393-6. PubMed PMID: 17768467. 13: May N, Anderson K. Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 3: Suxamethonium (succinylcholine) for RSI and intubation in head injury. Emerg Med J. 2012 Jun;29(6):511-4. doi: 10.1136/emermed-2012-201374.4. Review. PubMed PMID: 22635391. 14: Soto R, Jahr JS, Pavlin J, Sabo D, Philip BK, Egan TD, Rowe E, de Bie J, Woo T. Safety and Efficacy of Rocuronium With Sugammadex Reversal Versus Succinylcholine in Outpatient Surgery-A Multicenter, Randomized, Safety Assessor-Blinded Trial. Am J Ther. 2016 Nov/Dec;23(6):e1654-e1662. PubMed PMID: 25768376. 15: Eskildsen KZ, Gätke MR. [Danish Cholinesterase Research Unit diagnoses patients with prolonged paralysis after succinylcholine and mivacurium]. Ugeskr Laeger. 2014 Mar 17;176(12A). pii: V09130566. Review. Danish. PubMed PMID: 25350885. 16: Loughren MJ, Kilbourn J, Worth K, Burgert J, Gegel B, Johnson D. Comparison of muscle paralysis after intravenous and intraosseous administration of succinylcholine in Swine. J Spec Oper Med. 2014 Summer;14(2):35-7. PubMed PMID: 24952038. 17: Schuster F, Johannsen S, Moegele S, Metterlein T, Roewer N, Anetseder M. The effect of succinylcholine on malignant hyperthermia events in susceptible swine. BMC Anesthesiol. 2014 Mar 7;14:14. doi: 10.1186/1471-2253-14-14. PubMed PMID: 24606822; PubMed Central PMCID: PMC3973851. 18: Valdrighi JB, Fleming NW, Smith BK, Baker GL, White DA. Effects of cholinesterase inhibitors on the neuromuscular blocking action of suxamethonium. Br J Anaesth. 1994 Feb;72(2):237-9. PubMed PMID: 8110583. 19: PRAT H. [The action of curariform agents (gallamine triethiodide, suxamethonium bromide, d-tubocurarine) on heat production in animals]. Therapie. 1958;13(5):833-42. French. PubMed PMID: 13625196. 20: Shi Y, Storella RJ, Keykhah MM, Rosenberg H. Antagonism of suxamethonium-induced jaw muscle contracture in rats. Br J Anaesth. 1997 Mar;78(3):332-3. PubMed PMID: 9135319.