MedKoo Cat#: 462251 | Name: DI-87
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

DI-87 is an orally active and selective deoxycytidine kinase (dCK) inhibitor with an EC50 of 10.2 nM. DI-87 has antitumor activity and is used in combination therapy against tumors expressing dCK.

Chemical Structure

DI-87
CAS#2107280-55-5

Theoretical Analysis

MedKoo Cat#: 462251

Name: DI-87

CAS#: 2107280-55-5

Chemical Formula: C23H30N6O3S2

Exact Mass: 502.1821

Molecular Weight: 502.65

Elemental Analysis: C, 54.96; H, 6.02; N, 16.72; O, 9.55; S, 12.76

Price and Availability

Size Price Availability Quantity
5mg USD 1,250.00 2 Weeks
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Related CAS #
No Data
Synonym
DI-87; DI87; DI 87
IUPAC/Chemical Name
(R)-2-((1-(2-(4-methoxy-3-(2-morpholinoethoxy)phenyl)-5-methylthiazol-4-yl)ethyl)thio)pyrimidine-4,6-diamine
InChi Key
MFVINMPRHHUSBW-OAHLLOKOSA-N
InChi Code
InChI=1S/C23H30N6O3S2/c1-14-21(15(2)34-23-26-19(24)13-20(25)27-23)28-22(33-14)16-4-5-17(30-3)18(12-16)32-11-8-29-6-9-31-10-7-29/h4-5,12-13,15H,6-11H2,1-3H3,(H4,24,25,26,27)/t15-/m1/s1
SMILES Code
COC1=CC=C(C2=NC([C@@H](C)SC3=NC(N)=CC(N)=N3)=C(C)S2)C=C1OCCN4CCOCC4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 502.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Poddar S, Capparelli EV, Rosser EW, et al. Development and preclinical pharmacology of a novel dCK inhibitor, DI-87. Biochem Pharmacol. 2020;172:113742. doi:10.1016/j.bcp.2019.113742