SSTC3 | CAS#1242422-09-8 | CK1α activator

MedKoo Cat#: 462247 | Name: SSTC3

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SSTC3 is a casein kinase 1α (CK1α) activator (Kd = 32 nM) that inhibits WNT signaling (EC50 = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors.

Chemical Structure

SSTC3

CAS#1242422-09-8

Theoretical Analysis

MedKoo Cat#: 462247

Name: SSTC3

CAS#: 1242422-09-8

Chemical Formula: C23H17F3N4O3S2

Exact Mass: 518.0694

Molecular Weight: 518.53

Elemental Analysis: C, 53.28; H, 3.30; F, 10.99; N, 10.81; O, 9.26; S, 12.37

Price and Availability

Size	Price	Availability
5mg	USD 650.00	2 Weeks
10mg	USD 1,000.00	2 Weeks
50mg	USD 1,750.00	2 Weeks

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Related CAS #

No Data

Synonym

SSTC3; SSTC 3; SSTC 3

IUPAC/Chemical Name

4-(N-methyl-N-(4-(trifluoromethyl)phenyl)sulfamoyl)-N-(4-(pyridin-2-yl)thiazol-2-yl)benzamide

InChi Key

HSFAATUFWDDUGW-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H17F3N4O3S2/c1-30(17-9-7-16(8-10-17)23(24,25)26)35(32,33)18-11-5-15(6-12-18)21(31)29-22-28-20(14-34-22)19-4-2-3-13-27-19/h2-14H,1H3,(H,28,29,31)

SMILES Code

O=C(NC1=NC(C2=NC=CC=C2)=CS1)C3=CC=C(S(=O)(N(C)C4=CC=C(C(F)(F)F)C=C4)=O)C=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

SSTC3 is a CK1α activator (Kd = 32 nM) that inhibits WNT signaling (EC50 = 30 nM).

In vitro activity:

To be determined

In vivo activity:

SSTC3 attenuated the growth of a patient-derived metastatic colorectal cancer (CRC) xenograft, for which few therapies exist. SSTC3 exhibited minimal gastrointestinal toxicity compared to other classes of WNT inhibitors. CK1α was decreased in WNT-driven tumors relative to normal gastrointestinal tissue, and knocking down CK1α increased cellular sensitivity to SSTC3. Reference: Sci Signal. 2017 Jun 27;10(485):eaak9916. https://pubmed.ncbi.nlm.nih.gov/28655862/

	Solvent	mg/mL	mM	comments
Solubility
	DMSO	125.0	241.07

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 518.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Pan M, Hu T, Lyu J, Yin Y, Sun J, Wang Q, Xu L, Hu H, Wang C. CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling. Autophagy. 2024 Feb;20(2):311-328. doi: 10.1080/15548627.2023.2256135. Epub 2024 Jan 25. PMID: 37723657; PMCID: PMC10813568. 2. Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, Jin K, Nguyen DM, Sands LR, Marchetti F, Abreu MT, Cobb MH, Capobianco AJ, Lee E, Robbins DJ. Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors. Sci Signal. 2017 Jun 27;10(485):eaak9916. doi: 10.1126/scisignal.aak9916. PMID: 28655862; PMCID: PMC5555225.

In vitro protocol:

To be determined

In vivo protocol:

1: Pan M, Hu T, Lyu J, Yin Y, Sun J, Wang Q, Xu L, Hu H, Wang C. CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling. Autophagy. 2024 Feb;20(2):311-328. doi: 10.1080/15548627.2023.2256135. Epub 2024 Jan 25. PMID: 37723657; PMCID: PMC10813568. 2: Liu X, Zhou Q, Huang Y, Fan Z, Duan H, Wang M, Li Z, Xie L. Nicotinamide improves in vitro lens regeneration in a mouse capsular bag model. Stem Cell Res Ther. 2022 May 12;13(1):198. doi: 10.1186/s13287-022-02862-8. PMID: 35550648; PMCID: PMC9102750. 3: Rodriguez-Blanco J, Li B, Long J, Shen C, Yang F, Orton D, Collins S, Kasahara N, Ayad NG, McCrea HJ, Roussel MF, Weiss WA, Capobianco AJ, Robbins DJ. A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma. Clin Cancer Res. 2019 Feb 15;25(4):1379-1388. doi: 10.1158/1078-0432.CCR-18-1319. Epub 2018 Nov 28. PMID: 30487124; PMCID: PMC7142219. 4: Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, Jin K, Nguyen DM, Sands LR, Marchetti F, Abreu MT, Cobb MH, Capobianco AJ, Lee E, Robbins DJ. Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors. Sci Signal. 2017 Jun 27;10(485):eaak9916. doi: 10.1126/scisignal.aak9916. PMID: 28655862; PMCID: PMC5555225.

View History

Description:

Chemical Structure

Theoretical Analysis

Price and Availability

Preparing Stock Solutions

View History

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