PSB-KD107 | CAS#955121-65-0 | GPR18 agonist

MedKoo Cat#: 462235 | Name: PSB-KD107

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PSB-KD107 is an agonist of the Cannabinoid-Activated Orphan G‑Protein-Coupled Receptor GPR18. PSB-KD107 displayed significantly higher potency and efficacy than THC, determined in a GPR18-dependent β-arrestin recruitment assay, and were found to be selective versus the CB-sensitive receptors CB1, CB2, and GPR55.

Chemical Structure

PSB-KD107

CAS#955121-65-0

Theoretical Analysis

MedKoo Cat#: 462235

Name: PSB-KD107

CAS#: 955121-65-0

Chemical Formula: C20H22N6O2

Exact Mass: 378.1804

Molecular Weight: 378.44

Elemental Analysis: C, 63.48; H, 5.86; N, 22.21; O, 8.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

PSB-KD107; PSBKD107; PSB KD107

IUPAC/Chemical Name

9-(2-(1H-indol-3-yl)ethyl)-1,3-dimethyl-6,7,8,9-tetrahydropyrimido[2,1-f]purine-2,4(1H,3H)-dione

InChi Key

PUJKERUFRDZALE-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H22N6O2/c1-23-17-16(18(27)24(2)20(23)28)26-10-5-9-25(19(26)22-17)11-8-13-12-21-15-7-4-3-6-14(13)15/h3-4,6-7,12,21H,5,8-11H2,1-2H3

SMILES Code

O=C1C2=C(N=C3N2CCCN3CCC4=CNC5=C4C=CC=C5)N(C)C(N1C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 378.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Clara T. Schoeder, Andhika B. Mahardhika, Anna Drabczyńska, Katarzyna Kieć-Kononowicz, and Christa E. Müller. Discovery of Tricyclic Xanthines as Agonists of the Cannabinoid-Activated Orphan G-Protein-Coupled Receptor GPR18. ACS Medicinal Chemistry Letters Article ASAP. DOI: 10.1021/acsmedchemlett.0c00208.