PI-083 is a cell-permeable, reversible 20S proteasome inhibitor with IC50 values of 1 µM, 4.5 µM and 4.5 µM for CT-L, T-L and PGPH-L respectively. PI-083 exhibits CT-L (chymotrypsin-like) and cell proliferation inhibition selectively in ovarian, pancreatic, and breast cancer cells (T80-Hras, C7-Kras, and MCF-7, respectively) over their non-transformed counterparts (T80, C7, and MCF-10A), and induction of apoptosis with IC50 values of 3.7 µM in an MTT assay on bone marrow cells isolated from multiple myeloma patients in vitro. PI-083 shown to have anti-tumor activities in a nude mouse xenograft model implanted with MCF-7 and A549 cells in vivo
MedKoo Cat#: 462228
Name: PI-083
CAS#: 6298-15-3
Chemical Formula: C21H14ClN3O4S
Exact Mass: 439.0394
Molecular Weight: 439.87
Elemental Analysis: C, 57.34; H, 3.21; Cl, 8.06; N, 9.55; O, 14.55; S, 7.29
The following data is based on the product molecular weight 439.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
