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MedKoo Cat#: 146257 | Name: Physcione

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Physcion (also known as physcione) is a naturally occurring anthraquinone derivative found in plants like Rheum tanguticum and fungi such as Microsporum species. It has demonstrated anticancer, anti-inflammatory, hepatoprotective, and antimicrobial properties. In cancer research, physcion has shown potential as an anticancer agent. It induces apoptosis and autophagy in human nasopharyngeal carcinoma cells by generating reactive oxygen species (ROS), which activate the miR-27a/ZBTB10 axis and suppress the transcription factor Sp1 .

Chemical Structure

Physcione
Physcione
CAS#521-61-9

Theoretical Analysis

MedKoo Cat#: 146257

Name: Physcione

CAS#: 521-61-9

Chemical Formula: C16H12O5

Exact Mass: 284.0685

Molecular Weight: 284.27

Elemental Analysis: C, 67.60; H, 4.26; O, 28.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Physcione; Physcion;
IUPAC/Chemical Name
1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione
InChi Key
FFWOKTFYGVYKIR-UHFFFAOYSA-N
InChi Code
1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3
SMILES Code
COC1=CC(O)=C2C(=O)C3=C(C=C(C)C=C3O)C(=O)C2=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 284.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ghorbani A, Amiri MS, Hosseini A. Pharmacological properties of Rheum turkestanicum Janisch. Heliyon. 2019 Jun 23;5(6):e01986. doi: 10.1016/j.heliyon.2019.e01986. PMID: 31294125; PMCID: PMC6595136. 2: Ulus G. Antiangiogenic properties of lichen secondary metabolites. Phytother Res. 2021 Jun;35(6):3046-3058. doi: 10.1002/ptr.7023. Epub 2021 Feb 15. PMID: 33587324. 3: Wang D, Wang XH, Yu X, Cao F, Cai X, Chen P, Li M, Feng Y, Li H, Wang X. Pharmacokinetics of Anthraquinones from Medicinal Plants. Front Pharmacol. 2021 Apr 15;12:638993. doi: 10.3389/fphar.2021.638993. PMID: 33935728; PMCID: PMC8082241. 4: Jiao Y, Zuo Y. Ultrasonic extraction and HPLC determination of anthraquinones, aloe-emodine, emodine, rheine, chrysophanol and physcione, in roots of Polygoni multiflori. Phytochem Anal. 2009 Jul-Aug;20(4):272-8. doi: 10.1002/pca.1124. PMID: 19402184. 5: Hsu SC, Chung JG. Anticancer potential of emodin. Biomedicine (Taipei). 2012 Sep;2(3):108-116. doi: 10.1016/j.biomed.2012.03.003. Epub 2012 May 11. PMID: 32289000; PMCID: PMC7104001. 6: Okon E, Gaweł-Bęben K, Jarzab A, Koch W, Kukula-Koch W, Wawruszak A. Therapeutic Potential of 1,8-Dihydroanthraquinone Derivatives for Breast Cancer. Int J Mol Sci. 2023 Oct 31;24(21):15789. doi: 10.3390/ijms242115789. PMID: 37958772; PMCID: PMC10648492. 7: Genovese S, Tammaro F, Menghini L, Carlucci G, Epifano F, Locatelli M. Comparison of three different extraction methods and HPLC determination of the anthraquinones aloe-emodine, emodine, rheine, chrysophanol and physcione in the bark of Rhamnus alpinus L. (Rhamnaceae). Phytochem Anal. 2010 May- Jun;21(3):261-7. doi: 10.1002/pca.1195. PMID: 20024894. 8: Yu L, Qin J, Zhang M, Gao Y, Zhao Y. Research Progress on the Anti-Liver Cancer Mechanism and Toxicity of Rhubarb Anthraquinone. Drug Des Devel Ther. 2024 Dec 18;18:6089-6113. doi: 10.2147/DDDT.S489377. PMID: 39717199; PMCID: PMC11664478. 9: Adnan M, Rasul A, Hussain G, Shah MA, Sarfraz I, Nageen B, Riaz A, Khalid R, Asrar M, Selamoglu Z, Adem Ş, Sarker SD. Physcion and Physcion 8-O-β-D- glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities. Curr Drug Targets. 2021;22(5):488-504. doi: 10.2174/1389450121999201013154542. PMID: 33050858. 10: Simeral ML, Hafner JH. The Raman Active Vibrational Modes of Anthraquinones. Astrobiology. 2022 Oct;22(10):1165-1175. doi: 10.1089/ast.2021.0170. Epub 2022 Sep 7. PMID: 36070545. 11: Qi F, Zhang W, Xue Y, Geng C, Jin Z, Li J, Guo Q, Huang X, Lu X. Microbial production of the plant-derived fungicide physcion. Metab Eng. 2022 Nov;74:130-138. doi: 10.1016/j.ymben.2022.10.007. Epub 2022 Nov 1. PMID: 36328293. 12: Yang F, Li X, Zhang Y, Ren Y, Zhang J, Xiao K. Prediction of potential mechanisms of rhubarb therapy for colorectal cancer based on network pharmacological analysis and molecular docking. Medicine (Baltimore). 2024 Mar 22;103(12):e37477. doi: 10.1097/MD.0000000000037477. PMID: 38518016; PMCID: PMC10957024. 13: XunLi, Liu Y, Chu S, Yang S, Peng Y, Ren S, Wen B, Chen N. Physcion and physcion 8-O-β-glucopyranoside: A review of their pharmacology, toxicities and pharmacokinetics. Chem Biol Interact. 2019 Sep 1;310:108722. doi: 10.1016/j.cbi.2019.06.035. Epub 2019 Jun 18. PMID: 31226286. 14: Li X, Liu X, Yang F, Meng T, Li X, Yan Y, Xiao K. Mechanism of Dahuang Mudan Decotion in the treatment of colorectal cancer based on network pharmacology and experimental validation. Heliyon. 2024 May 29;10(11):e32136. doi: 10.1016/j.heliyon.2024.e32136. PMID: 38882337; PMCID: PMC11176830. 15: Li X, Chu S, Liu Y, Chen N. Neuroprotective Effects of Anthraquinones from Rhubarb in Central Nervous System Diseases. Evid Based Complement Alternat Med. 2019 May 16;2019:3790728. doi: 10.1155/2019/3790728. PMID: 31223328; PMCID: PMC6541978. 16: Nowak-Perlak M, Ziółkowski P, Woźniak M. A promising natural anthraquinones mediated by photodynamic therapy for anti-cancer therapy. Phytomedicine. 2023 Oct;119:155035. doi: 10.1016/j.phymed.2023.155035. Epub 2023 Aug 16. PMID: 37603973. 17: Nguyen LTH, Ahn SH, Shin HM, Yang IJ. Anti-Psoriatic Effect of Rheum palmatum L. and Its Underlying Molecular Mechanisms. Int J Mol Sci. 2022 Dec 15;23(24):16000. doi: 10.3390/ijms232416000. PMID: 36555642; PMCID: PMC9781959. 18: Wang B, Wang Z, Zhou Z, Liu G, Jiang Z, Zheng M, Geng W. Inhibition of 6-phosphogluconate dehydrogenase suppresses esophageal squamous cell carcinoma growth and enhances the anti-tumor effects of metformin via the AMPK/mTOR pathway. Mol Cancer. 2025 Mar 26;24(1):97. doi: 10.1186/s12943-025-02302-0. PMID: 40140842; PMCID: PMC11938747. 19: Hou X, Sun M, Bao T, Xie X, Wei F, Wang S. Recent advances in screening active components from natural products based on bioaffinity techniques. Acta Pharm Sin B. 2020 Oct;10(10):1800-1813. doi: 10.1016/j.apsb.2020.04.016. Epub 2020 Jun 3. PMID: 33163336; PMCID: PMC7606101. 20: Chien SC, Wu YC, Chen ZW, Yang WC. Naturally occurring anthraquinones: chemistry and therapeutic potential in autoimmune diabetes. Evid Based Complement Alternat Med. 2015;2015:357357. doi: 10.1155/2015/357357. Epub 2015 Mar 18. PMID: 25866536; PMCID: PMC4381678.