Tramazoline is an imidazoline derivative that acts as a selective α1 adrenergic receptor agonist, primarily used as a topical nasal decongestant. Its pharmacological activity stems from vasoconstriction of nasal mucosal blood vessels, leading to reduced edema and improved airflow. In vitro studies show tramazoline has high affinity for α1A α 1D receptors (Ki values in the low nanomolar range), while demonstrating negligible activity at β-adrenergic or central nervous system receptors, minimizing systemic side effects. In vivo, intranasal administration in humans produces rapid onset of decongestion (within 5–10 minutes) with effects lasting 6–8 hours.
MedKoo Cat#: 574434
Name: Tramazoline HCl
CAS#: 3715-90-0 (HCl)
Chemical Formula: C13H18ClN3
Exact Mass: 251.1189
Molecular Weight: 251.76
Elemental Analysis: C, 62.02; H, 7.21; Cl, 14.08; N, 16.69
The following data is based on the product molecular weight 251.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
