MedKoo Cat#: 574432 | Name: TCB-2 HBr
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TCB-2 is a high affinity 5-HT2A receptor agonist that stimulates IP3 accumulation in NIH3T3 cells stably expressing rat 5-HT2A receptors. It induces head twitches and hypothermia in mice following i.p. administration.

Chemical Structure

TCB-2 HBr
TCB-2 HBr
CAS#912342-28-0 (HBr)

Theoretical Analysis

MedKoo Cat#: 574432

Name: TCB-2 HBr

CAS#: 912342-28-0 (HBr)

Chemical Formula: C11H13Br2NO2

Exact Mass: 0.0000

Molecular Weight: 351.04

Elemental Analysis: C, 37.64; H, 3.73; Br, 45.52; N, 3.99; O, 9.12

Price and Availability

Size Price Availability Quantity
10mg USD 585.00 2 Weeks
50mg USD 1,850.00 2 Weeks
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Related CAS #
912342-28-0 (HBr) 912342-21-3 (free base)
Synonym
TCB-2, TCB2, TCB 2; TCB-2 HBr; TCB-2 Hydrobromide;
IUPAC/Chemical Name
(4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide
InChi Key
UHROCWIQCWPPOT-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H12BrNO2.BrH/c1-14-9-4-8(12)11(15-2)7-3-6(5-13)10(7)9;/h3-4H,5,13H2,1-2H3;1H
SMILES Code
NCC1=CC2=C(OC)C(Br)=CC(OC)=C21.[H]Br
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 351.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. McLean et al (2006) 1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists. J.Med.Chem. 49 5794 PMID: 16970404 2. Fox et al (2010) The serotonin 5-HT2A receptor agonist TCB-2: a behavioral and neurophysiological analysis. Psychopharmacology 212 13 PMID: 19823806 3. Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. PLoS One 6 e21395 PMID: 21789169