MedKoo Cat#: 574420 | Name: S-25585
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

S-25585 is a neuropeptide Y (NPY) Y5 receptor antagonist that does not produce a conditioned taste aversion, suppress sodium appetite or cause pica in rats. It significantly inhibits NPY-induced feeding but not through blockade of Y5 receptors.

Chemical Structure

S-25585
S-25585
CAS#263849-50-9

Theoretical Analysis

MedKoo Cat#: 574420

Name: S-25585

CAS#: 263849-50-9

Chemical Formula: C22H23F3N4O6S

Exact Mass: 528.1290

Molecular Weight: 528.50

Elemental Analysis: C, 50.00; H, 4.39; F, 10.78; N, 10.60; O, 18.16; S, 6.07

Price and Availability

Size Price Availability Quantity
10mg USD 450.00 2 Weeks
50mg USD 1,300.00 2 Weeks
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Related CAS #
No Data
Synonym
S-25585, S25585, S 25585
IUPAC/Chemical Name
1-Benzoyl-2-[[trans-4-[[[[2-nitro-4-(trifluoromethyl)phenyl]sulfonyl]amino]methyl]cyclohexyl]carbonyl]hydrazine
InChi Key
BRMJFKLHWFZWOQ-KOMQPUFPSA-N
InChi Code
InChI=1S/C22H23F3N4O6S/c23-22(24,25)17-10-11-19(18(12-17)29(32)33)36(34,35)26-13-14-6-8-16(9-7-14)21(31)28-27-20(30)15-4-2-1-3-5-15/h1-5,10-12,14,16,26H,6-9,13H2,(H,27,30)(H,28,31)/t14-,16-
SMILES Code
O=C(NNC(C1=CC=CC=C1)=O)[C@H]2CC[C@H](CNS(=O)(C3=CC=C(C(F)(F)F)C=C3[N+]([O-])=O)=O)CC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 528.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Beauverger et al (2005) Functional characterization of human neuropeptide Y receptor subtype 5 specific antagonists using a luciferase reporter gene assay. Cell.Signal. 17 489 PMID: 15601626 2: Della-Zuana et al (2004) A potent and selective NPY Y5 antagonist reduces food intake but not through blockade of the NPY Y5 receptor. Int.J.Obes. 28 628 3: Kamiji and Inui (2007) Neuropeptide Y receptor selective ligands in the treatment of obesity. 28 664