Furafylline | CAS#80288-49-9 | cytochrome P450 inhibitor

MedKoo Cat#: 462156 | Name: Furafylline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Furafylline is a selective inhibitor of human cytochrome P450. t was originally introduced as a bronchodilator with extended duration compared to theophylline, but then subsequently reported to inhibit the oxidation of caffeine, a reaction catalyzed by CYP1A2.

Chemical Structure

Furafylline

CAS#80288-49-9

Theoretical Analysis

MedKoo Cat#: 462156

Name: Furafylline

CAS#: 80288-49-9

Chemical Formula: C12H12N4O3

Exact Mass: 260.0909

Molecular Weight: 260.25

Elemental Analysis: C, 55.38; H, 4.65; N, 21.53; O, 18.44

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Furafylline

IUPAC/Chemical Name

3-(2-furanylmethyl)-3,9-dihydro-1,8-dimethyl-1H-purine-2,6-dione

InChi Key

KGQZGCIVHYLPBH-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H12N4O3/c1-7-13-9-10(14-7)16(6-8-4-3-5-19-8)12(18)15(2)11(9)17/h3-5H,6H2,1-2H3,(H,13,14)

SMILES Code

CN1C(N(CC2=CC=CO2)C(N=C(C)N3)=C3C1=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 260.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sesardic, D., Boobis, A.R., Murray, B.P., et al. Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man. British Journal of Clinical Pharmacology 29(6), 651-663 (1990). 2: Tarrus, E., Cami, J., Roberts, D.J., et al. Accumulation of caffeine in healthy volunteers treated with furafylline. British Journal of Clinical Pharmacology 23(1), 9-18 (1987).