UVI3003 | CAS#847239-17-2 | RXR Antagonist

MedKoo Cat#: 532876 | Name: UVI3003

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UVI3003 is a RXR antagonist. It displays high RXR binding affinity. UVI3003 does not affect the corepressor interaction capacity of the RARα subunit within the context of the RAR-RXR heterodimer.

Chemical Structure

UVI3003

CAS#847239-17-2

Theoretical Analysis

MedKoo Cat#: 532876

Name: UVI3003

CAS#: 847239-17-2

Chemical Formula: C28H36O4

Exact Mass: 436.2614

Molecular Weight: 436.59

Elemental Analysis: C, 77.03; H, 8.31; O, 14.66

Price and Availability

Size	Price	Availability
50mg	USD 650.00	2 Weeks
100mg	USD 1,050.00	2 Weeks
200mg	USD 1,650.00	2 Weeks
500mg	USD 2,950.00	2 Weeks
1g	USD 4,250.00	2 Weeks
2g	USD 7,450.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

UVI3003, UVI 3003, UVI-3003

IUPAC/Chemical Name

(2E)-3-{4-hydroxy-3-[5,5,8,8-tetramethyl-3-(pentyloxy)-5,6,7,8-tetrahydronaphthalen-2-yl]phenyl}prop-2-enoic acid

InChi Key

APJSHECCIRQQDV-ZRDIBKRKSA-N

InChi Code

InChI=1S/C28H36O4/c1-6-7-8-15-32-25-18-23-22(27(2,3)13-14-28(23,4)5)17-21(25)20-16-19(9-11-24(20)29)10-12-26(30)31/h9-12,16-18,29H,6-8,13-15H2,1-5H3,(H,30,31)/b12-10+

SMILES Code

O=C(O)/C=C/C1=CC=C(O)C(C2=C(OCCCCC)C=C3C(C)(C)CCC(C)(C)C3=C2)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 436.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sun H, Liu Y, Wang X, Shu L. A network pharmacology-based method to explore the therapeutic effect of honokiol on diabetes with comorbid depression in mice. Eur J Pharmacol. 2024 Jul 15;975:176642. doi: 10.1016/j.ejphar.2024.176642. Epub 2024 May 14. PMID: 38754538. 2: Wang J, Xue X, Zhao X, Luo L, Liu J, Dai S, Zhang F, Wu R, Liu Y, Peng C, Li Y. Forsythiaside A alleviates acute lung injury by inhibiting inflammation and epithelial barrier damages in lung and colon through PPAR-γ/RXR-α complex. J Adv Res. 2024 Jun;60:183-200. doi: 10.1016/j.jare.2023.08.006. Epub 2023 Aug 12. PMID: 37579917; PMCID: PMC11156707. 3: Chang RC, Joloya EM, Li Z, Shoucri BM, Shioda T, Blumberg B. miR-223 Plays a Key Role in Obesogen-Enhanced Adipogenesis in Mesenchymal Stem Cells and in Transgenerational Obesity. Endocrinology. 2023 Mar 13;164(5):bqad027. doi: 10.1210/endocr/bqad027. PMID: 36740725; PMCID: PMC10282922. 4: Mengeling BJ, Vetter LF, Furlow JD. Retinoid-X receptor agonists increase thyroid hormone competence in lower jaw remodeling of pre-metamorphic Xenopus laevis tadpoles. PLoS One. 2022 Apr 13;17(4):e0266946. doi: 10.1371/journal.pone.0266946. PMID: 35417489; PMCID: PMC9007347. 5: Latta L, Knebel I, Bleil C, Stachon T, Katiyar P, Zussy C, Fries FN, Käsmann- Kellner B, Seitz B, Szentmáry N. Similarities in DSG1 and KRT3 Downregulation through Retinoic Acid Treatment and PAX6 Knockdown Related Expression Profiles: Does PAX6 Affect RA Signaling in Limbal Epithelial Cells? Biomolecules. 2021 Nov 8;11(11):1651. doi: 10.3390/biom11111651. PMID: 34827649; PMCID: PMC8615883. 6: Oguro A, Fujita K, Ishihara Y, Yamamoto M, Yamazaki T. DHA and Its Metabolites Have a Protective Role against Methylmercury-Induced Neurotoxicity in Mouse Primary Neuron and SH-SY5Y Cells. Int J Mol Sci. 2021 Mar 22;22(6):3213. doi: 10.3390/ijms22063213. PMID: 33809931; PMCID: PMC8004243. 7: Murillo-Rodríguez E, Millán-Aldaco D, Arankowsky-Sandoval G, Yamamoto T, Cid L, Monteiro D, Rocha NB, Telles-Correia D, Teixeira DS, Veras AB, Budde H, Machado S, Imperatori C, Torterolo P. The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats. Psychopharmacology (Berl). 2020 Jul;237(7):2055-2073. doi: 10.1007/s00213-020-05518-8. Epub 2020 May 30. PMID: 32472163. 8: Xu H, Wang Y, Zhao J, Jurutka PW, Huang D, Liu L, Zhang L, Wang S, Chen Y, Cheng S. Triterpenes from Poria cocos are revealed as potential retinoid X receptor selective agonists based on cell and in silico evidence. Chem Biol Drug Des. 2020 May;95(5):493-502. doi: 10.1111/cbdd.13610. Epub 2020 Mar 9. PMID: 31444840. 9: Ishihara Y, Sakurai H, Oguro A, Tsuji M, Vogel CFA, Yamazaki T. Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis. J Steroid Biochem Mol Biol. 2019 Oct;193:105421. doi: 10.1016/j.jsbmb.2019.105421. Epub 2019 Jun 29. PMID: 31265900. 10: Zuo Y, Huang L, Enkhjargal B, Xu W, Umut O, Travis ZD, Zhang G, Tang J, Liu F, Zhang JH. Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats. J Neuroinflammation. 2019 Feb 21;16(1):47. doi: 10.1186/s12974-019-1432-5. PMID: 30791908; PMCID: PMC6385420. 11: Clemens V, Regen F, Le Bret N, Heuser I, Hellmann-Regen J. Anti-inflammatory effects of minocycline are mediated by retinoid signaling. BMC Neurosci. 2018 Sep 21;19(1):58. doi: 10.1186/s12868-018-0460-x. PMID: 30241502; PMCID: PMC6151010. 12: Mengeling BJ, Goodson ML, Furlow JD. RXR Ligands Modulate Thyroid Hormone Signaling Competence in Young Xenopus laevis Tadpoles. Endocrinology. 2018 Jul 1;159(7):2576-2595. doi: 10.1210/en.2018-00172. PMID: 29762675; PMCID: PMC6692881. 13: Hebert SL, Fitzpatrick KR, McConnell SA, Cucak A, Yuan C, McLoon LK. Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro. Exp Cell Res. 2017 Dec 1;361(1):101-111. doi: 10.1016/j.yexcr.2017.10.007. Epub 2017 Oct 7. PMID: 29017757; PMCID: PMC6546114. 14: Zhu J, Janesick A, Wu L, Hu L, Tang W, Blumberg B, Shi H. The unexpected teratogenicity of RXR antagonist UVI3003 via activation of PPARγ in Xenopus tropicalis. Toxicol Appl Pharmacol. 2017 Jan 1;314:91-97. doi: 10.1016/j.taap.2016.11.014. Epub 2016 Nov 25. PMID: 27894914; PMCID: PMC5183475. 15: Mihály J, Gericke J, Lucas R, de Lera AR, Alvarez S, Törőcsik D, Rühl R. TSLP expression in the skin is mediated via RARγ-RXR pathways. Immunobiology. 2016 Feb;221(2):161-5. doi: 10.1016/j.imbio.2015.09.013. Epub 2015 Sep 10. PMID: 26531761. 16: Zheng L, Yu J, Shi H, Xia L, Xin Q, Zhang Q, Zhao H, Luo J, Jin W, Li D, Zhou J. Quantitative toxicoproteomic analysis of zebrafish embryos exposed to a retinoid X receptor antagonist UVI3003. J Appl Toxicol. 2015 Sep;35(9):1049-57. doi: 10.1002/jat.3099. Epub 2015 Jan 11. PMID: 25581642. 17: Sun J, Narayanasamy S, Curley RW Jr, Harrison EH. β-Apo-13-carotenone regulates retinoid X receptor transcriptional activity through tetramerization of the receptor. J Biol Chem. 2014 Nov 28;289(48):33118-24. doi: 10.1074/jbc.M114.610501. Epub 2014 Oct 16. PMID: 25324544; PMCID: PMC4246072. 18: Zheng L, Xu T, Li D, Zhou J. A representative retinoid X receptor antagonist UVI3003 induced teratogenesis in zebrafish embryos. J Appl Toxicol. 2015 Mar;35(3):280-6. doi: 10.1002/jat.3051. Epub 2014 Sep 3. PMID: 25186191. 19: Zhu J, Shi H, Zhu P, Hu L, Wu L, Yang Y, Rotchell JM. Effects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos. Environ Toxicol Pharmacol. 2014 Jul;38(1):153-62. doi: 10.1016/j.etap.2014.05.010. Epub 2014 May 27. PMID: 24950139. 20: Wang Y, Han Y, Yang J, Wang Z, Liu L, Wang W, Zhou L, Wang D, Tan X, Fu C, Jose PA, Zeng C. Relaxant effect of all-trans-retinoic acid via NO-sGC-cGMP pathway and calcium-activated potassium channels in rat mesenteric artery. Am J Physiol Heart Circ Physiol. 2013 Jan 1;304(1):H51-7. doi: 10.1152/ajpheart.00240.2012. Epub 2012 Nov 2. PMID: 23125214; PMCID: PMC3543680.