SN-2 | CAS# 823218-99-1 | TRPML3 channel activator

MedKoo Cat#: 574410 | Name: SN-2

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SN-2 is a selective TRPML3 channel activator.

Chemical Structure

SN-2

CAS#823218-99-1

Theoretical Analysis

MedKoo Cat#: 574410

Name: SN-2

CAS#: 823218-99-1

Chemical Formula: C17H21NO

Exact Mass: 255.1623

Molecular Weight: 255.36

Elemental Analysis: C, 79.96; H, 8.29; N, 5.49; O, 6.27

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 450.00	2 Weeks
50mg	USD 1,300.00	2 Weeks

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Related CAS #

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Synonym

SN-2, SN2, SN 2

IUPAC/Chemical Name

3-mesityl-3a,4,5,6,7,7a-hexahydro-4,7-methanobenzo[d]isoxazole

InChi Key

WKLZNTYMDOPBSE-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H21NO/c1-9-6-10(2)14(11(3)7-9)16-15-12-4-5-13(8-12)17(15)19-18-16/h6-7,12-13,15,17H,4-5,8H2,1-3H3

SMILES Code

CC1=CC(C)=CC(C)=C1C2=NOC3C2C4CCC3C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

SN-2 is a selective TRPML3 channel activator (EC50 = 1.13 μM).

In vitro activity:

This study identifies ML-SA1 and SN-2 as potent inhibitors against DENV2 and ZIKV, offering potential candidates for antiviral drug development. ML-SA1, a TRPML agonist, demonstrated dose-dependent inhibition of DENV2 and ZIKV, mainly affecting viral entry. SN-2, a TRPML3 activator, showed similar antiviral effects, while MK6-83, a specific TRPML1 agonist, was ineffective. Reference: Antiviral Res. 2020 Oct;182:104922. https://pubmed.ncbi.nlm.nih.gov/32858116/

In vivo activity:

To be determined

	Solvent	mg/mL	mM
Solubility
	DMSO	25.5	100.00
	Ethanol	25.5	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 255.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Xia Z, Ren Y, Li S, Xu J, Wu Y, Cao Z. ML-SA1 and SN-2 inhibit endocytosed viruses through regulating TRPML channel expression and activity. Antiviral Res. 2021 Nov;195:105193. doi: 10.1016/j.antiviral.2021.105193. Epub 2021 Oct 20. PMID: 34687820. 2. Xia Z, Wang L, Li S, Tang W, Sun F, Wu Y, Miao L, Cao Z. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020 Oct;182:104922. doi: 10.1016/j.antiviral.2020.104922. Epub 2020 Aug 26. PMID: 32858116.

In vitro protocol:

In vivo protocol: