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MedKoo Cat#: 565345 | Name: MK-0626 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MK-0626 is a Dipeptidyl peptidase IV (DPP-4) inhibitor, improving neovascularization by increasing both the number of circulating endothelial progenitor cells and endothelial nitric oxide synthetase expression.

Chemical Structure

MK-0626 free base
MK-0626 free base
CAS#690257-74-0 (free base),

Theoretical Analysis

MedKoo Cat#: 565345

Name: MK-0626 free base

CAS#: 690257-74-0 (free base),

Chemical Formula: C22H24F2N6O2

Exact Mass: 442.1929

Molecular Weight: 442.47

Elemental Analysis: C, 59.72; H, 5.47; F, 8.59; N, 18.99; O, 7.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
690256-74-7 (HCl) 690257-74-0 (free base)
Synonym
MK0626; MK 0626; MK-0626;
IUPAC/Chemical Name
(2S,3S)-3-Amino-4-(3,3-Difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide
InChi Key
HOLMVLAGEPDFQK-OALUTQOASA-N
InChi Code
InChI=1S/C22H24F2N6O2/c1-28(2)20(31)18(19(25)21(32)29-10-9-22(23,24)12-29)15-5-3-14(4-6-15)16-7-8-17-26-13-27-30(17)11-16/h3-8,11,13,18-19H,9-10,12,25H2,1-2H3/t18-,19-/m0/s1
SMILES Code
O=C(N(C)C)[C@@H](C1=CC=C(C2=CN3C(C=C2)=NC=N3)C=C1)[C@H](N)C(N4CC(F)(F)CC4)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 442.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Golldack A, Henke B, Bergmann B, Wiechert M, Erler H, Blancke Soares A, Spielmann T, Beitz E. Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale. PLoS Pathog. 2017 Feb 8;13(2):e1006172. doi: 10.1371/journal.ppat.1006172. eCollection 2017 Feb. PubMed PMID: 28178358; PubMed Central PMCID: PMC5298233. 1: Ohyama T, Sato K, Yamazaki Y, Hashizume H, Horiguchi N, Kakizaki S, Mori M, Kusano M, Yamada M. MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in ob/ob mice. World J Gastroenterol. 2014 Nov 21;20(43):16227-35. doi: 10.3748/wjg.v20.i43.16227. PubMed PMID: 25473177; PubMed Central PMCID: PMC4239511. 2: Jin L, Lim SW, Doh KC, Piao SG, Jin J, Heo SB, Chung BH, Yang CW. Dipeptidyl peptidase IV inhibitor MK-0626 attenuates pancreatic islet injury in tacrolimus-induced diabetic rats. PLoS One. 2014 Jun 24;9(6):e100798. doi: 10.1371/journal.pone.0100798. eCollection 2014. PubMed PMID: 24959755; PubMed Central PMCID: PMC4069160. 3: Shih CM, Chen YH, Lin YW, Tsao NW, Wu SC, Kao YT, Chiang KH, Li CY, Chang NC, Lin CY, Huang CY, Lin FY. MK-0626, a dipeptidyl peptidase-4 inhibitor, improves neovascularization by increasing both the number of circulating endothelial progenitor cells and endothelial nitric oxide synthetase expression. Curr Med Chem. 2014 Jun;21(17):2012-22. PubMed PMID: 24059225.