MedKoo Cat#: 574403 | Name: SGS-518 oxalate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SGS-518 oxalate is a selective antagonist of the 5-HT6 subtype of the serotonin receptor. It may be useful for the treatment of cognitive impairment that is associated with schizophrenia and Alzheimer's disease.

Chemical Structure

SGS-518 oxalate
SGS-518 oxalate
CAS#445441-27-0

Theoretical Analysis

MedKoo Cat#: 574403

Name: SGS-518 oxalate

CAS#: 445441-27-0

Chemical Formula: C23H24F2N2O7S

Exact Mass: 510.1272

Molecular Weight: 510.51

Elemental Analysis: C, 54.11; H, 4.74; F, 7.44; N, 5.49; O, 21.94; S, 6.28

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Synonym
SGS-518 oxalate
IUPAC/Chemical Name
1-methyl-3-(1-methylpiperidin-4-yl)-1H-indol-5-yl 2,6-difluorobenzenesulfonate oxalate
InChi Key
XQGFYENETWVJEU-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H22F2N2O3S.C2H2O4/c1-24-10-8-14(9-11-24)17-13-25(2)20-7-6-15(12-16(17)20)28-29(26,27)21-18(22)4-3-5-19(21)23;3-1(4)2(5)6/h3-7,12-14H,8-11H2,1-2H3;(H,3,4)(H,5,6)
SMILES Code
CN2C1=CC=C(OS(C4=C(F)C=CC=C4F)(=O)=O)C=C1C(C3CCN(C)CC3)=C2.OC(C(O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 510.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Kim et al (2008) New serotonin 5-HT6 ligands from common feature pharmacophore hypotheses. J.Chem.Inf.Model. 48 197 PMID: 18044950 2. Romero et al (2006) Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways. Br.J.Pharmocol. 148 1133 PMID: 16865095