IUPAC/Chemical Name
Benzohydroximic acid, p-bromothio-, S-diethylaminoethyl ester, hydrochloride
InChi Key
VZVVODCSXDRMOP-IWSIBTJSSA-N
InChi Code
InChI=1S/C13H16BrN3O3S.ClH/c1-8(18)15-12(16-9(2)19)7-21-13(17-20)10-3-5-11(14)6-4-10;/h3-6,12,20H,7H2,1-2H3,(H,15,18)(H,16,19);1H/b17-13+;
SMILES Code
O/N=C(SCC(NC(C)=O)NC(C)=O)\C1=CC=C(Br)C=C1.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
410.71
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Kokshareva NV. Terapevticheskaia éffektivnost' dietiksima pri otravlenii karbaminovymi pestitsidami antikholinésteraznogo deĭstviia [Therapeutic effectiveness of diethyxime in poisoning by anticholinesterase-action carbamate pesticides]. Farmakol Toksikol. 1982 Jul-Aug;45(4):61-4. Russian. PMID: 7128789.
3: Zabrodskiĭ PF, Kirichuk VF, Gryzunov AV. Mekhanizm vliianiia reaktivatora kholinésterazy diétiksima na razlichnye modeli formirovaniia giperchuvstvitel'nosti zamedlennogo tipa pri ostroĭ intoksikatsii dikhlorétanom [The mechanism of the effect of the cholinesterase reactivator diethyxime on different models of the development of delayed hypersensitivity in acute dichloroethane poisoning]. Eksp Klin Farmakol. 1998 Jan-Feb;61(1):57-9. Russian. PMID: 9575415.
4: Beznosko BK, Voronov IB, Feĭgman EE, Krivenchuk VE. O tsentral'nom deĭstvii novogo reaktivatora kholinésteraz diétiksima [Central action of a new cholinesterase reactivator, diethyxime]. Farmakol Toksikol. 1977 Sep- Oct;40(5):531-5. Russian. PMID: 923773.
5: Ershova LK, Kokshareva NV. Reaktsiia tsentral'noĭ nervnoĭ sistemy na dietiksim i fenobarbital posle vozdeĭstviia triortokrezilfosfata [Reaction of the central nervous system to diethyxime and phenobarbital after the application of triorthocresyl phosphate]. Fiziol Zh. 1985 Jul-Aug;31(4):439-45. Russian. PMID: 4043417.
6: Das Gupta S, Ghosh AK, Moorthy MV, Jaiswal DK, Chowdhri BL, Purnand, Pant BP. Comparative studies of pralidoxime, trimedoxime, obidoxime and diethyxime in acute fluostigmine poisoning in rats. Pharmazie. 1982 Aug;37(8):605. PMID: 6755496.
7: Kagan IuS, Kokshareva NV, Sasinovich LM, Krivenchuk VE. Eksperimental'nye dannye o novom reaktivatore kholinésterazy iz gruppy tiogidroksimovykh éfirov [Experimental data on a new cholinesterase reactivator from the group of thiohydroximic esters]. Farmakol Toksikol. 1975 May-Jun;38(3):294-8. Russian. PMID: 1227901.
8: Jaiswal DK, Pant BP, Purnanand, Das Gupta S, Ghosh AK, Moorthy MV. Studies on thiohydroximic thioesters in combination with pyridine aldoximes in acute organophosphorus poisoning. Pharmazie. 1983 May;38(5):349. PMID: 6611636.
