Prinomastat hydrochloride | CAS#1435779-45-5 | MMP inhibitor

MedKoo Cat#: 462188 | Name: Prinomastat hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prinomastat hydrochloride is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor. Prinomastat hydrochloride inhibits MMP-2, MMP-3 and MMP-9. It can cross blood-brain barrier and has antitumor activity.

Chemical Structure

Prinomastat hydrochloride

CAS#1435779-45-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 462188

Name: Prinomastat hydrochloride

CAS#: 1435779-45-5 (HCl)

Chemical Formula: C18H22ClN3O5S2

Exact Mass: 459.0689

Molecular Weight: 459.96

Elemental Analysis: C, 47.00; H, 4.82; Cl, 7.71; N, 9.14; O, 17.39; S, 13.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

192329-42-3 (free base) 1435779-45-5 (HCl)

Synonym

Prinomastat hydrochloride; AG3340 hydrochloride; AG3340 hydrochloride

IUPAC/Chemical Name

(S)-2,2-Dimethyl-4-((p-(4-pyridyloxy)phenyl)sulfonyl)-3-thiomorpholinecarbohydroxamic acid hydrochloride

InChi Key

UQGWXXLNXBRNBU-NTISSMGPSA-N

InChi Code

InChI=1S/C18H21N3O5S2.ClH/c1-18(2)16(17(22)20-23)21(11-12-27-18)28(24,25)15-5-3-13(4-6-15)26-14-7-9-19-10-8-14;/h3-10,16,23H,11-12H2,1-2H3,(H,20,22);1H/t16-;/m0./s1

SMILES Code

O=C([C@@H]1N(S(=O)(C2=CC=C(OC3=CC=NC=C3)C=C2)=O)CCSC1(C)C)NO.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 459.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sørensen MD, Blaehr LK, Christensen MK, et al. Cyclic phosphinamides and phosphonamides, novel series of potent matrix metalloproteinase inhibitors with antitumour activity. Bioorg Med Chem. 2003;11(24):5461‐5484. doi:10.1016/j.bmc.2003.09.015 2: Blavier L, Lazaryev A, Shi XH, Dorey FJ, Shackleford GM, DeClerck YA. Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT). Cancer Biol Ther. 2010;10(2):198‐208. doi:10.4161/cbt.10.2.12193. 3: Shalinsky DR, Brekken J, Zou H, et al. Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials. Ann N Y Acad Sci. 1999;878:236‐270. doi:10.1111/j.1749-6632.1999.tb07689.x. 4: Ozerdem U, Mach-Hofacre B, Cheng L, et al. The effect of prinomastat (AG3340), a potent inhibitor of matrix metalloproteinases, on a subacute model of proliferative vitreoretinopathy. Curr Eye Res. 2000;20(6):447‐453.