MedKoo Cat#: 462187 | Name: BRD0705
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor. BRD0705 can be used for acute myeloid leukemia.

Chemical Structure

BRD0705
BRD0705
CAS#2056261-41-5

Theoretical Analysis

MedKoo Cat#: 462187

Name: BRD0705

CAS#: 2056261-41-5

Chemical Formula: C20H23N3O

Exact Mass: 321.1841

Molecular Weight: 321.42

Elemental Analysis: C, 74.74; H, 7.21; N, 13.07; O, 4.98

Price and Availability

Size Price Availability Quantity
50mg USD 1,250.00 2 Weeks
100mg USD 2,250.00 2 Weeks
200mg USD 3,850.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
BRD0705; BRD-0705; BRD 0705;
IUPAC/Chemical Name
(S)-4-ethyl-7,7-dimethyl-4-phenyl-1,2,4,6,7,8-hexahydro-5H-pyrazolo[3,4-b]quinolin-5-one
InChi Key
NCKLQXXBRWCYMA-FQEVSTJZSA-N
InChi Code
InChI=1S/C20H23N3O/c1-4-20(13-8-6-5-7-9-13)14-12-21-23-18(14)22-15-10-19(2,3)11-16(24)17(15)20/h5-9,12H,4,10-11H2,1-3H3,(H2,21,22,23)/t20-/m0/s1
SMILES Code
O=C1CC(C)(C)CC2=C1[C@@](CC)(C3=CC=CC=C3)C4=CNNC4=N2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 321.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wagner FF, Benajiba L, Campbell AJ, Weïwer M, Sacher JR, Gale JP, Ross L, Puissant A, Alexe G, Conway A, Back M, Pikman Y, Galinsky I, DeAngelo DJ, Stone RM, Kaya T, Shi X, Robers MB, Machleidt T, Wilkinson J, Hermine O, Kung A, Stein AJ, Lakshminarasimhan D, Hemann MT, Scolnick E, Zhang YL, Pan JQ, Stegmaier K, Holson EB. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10(431):eaam8460. doi: 10.1126/scitranslmed.aam8460. PMID: 29515000; PMCID: PMC6553635. 2: Dey S, Eisa A, Kline D, Wagner FF, Abeysirigunawardena S, Vijayaraghavan S. Roles of glycogen synthase kinase 3 alpha and calcineurin in regulating the ability of sperm to fertilize eggs. FASEB J. 2020 Jan;34(1):1247-1269. doi: 10.1096/fj.201902163R. Epub 2019 Nov 29. PMID: 31914663; PMCID: PMC7539848. 3: Kabi M, Khamamkar A, Kyei-Baffour K, Weïwer M, Vijayaraghavan S, Dey S. A non-hormonal reversible contraceptive targeting GSK3α, a protein kinase, essential for epididymal sperm maturation. Andrology. 2025 Jan 3. doi: 10.1111/andr.13838. Epub ahead of print. PMID: 39748754. 4: Hinze L, Pfirrmann M, Karim S, Degar J, McGuckin C, Vinjamur D, Sacher J, Stevenson KE, Neuberg DS, Orellana E, Stanulla M, Gregory RI, Bauer DE, Wagner FF, Stegmaier K, Gutierrez A. Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias. Cancer Cell. 2019 Apr 15;35(4):664-676.e7. doi: 10.1016/j.ccell.2019.03.004. PMID: 30991026; PMCID: PMC6541931.