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MedKoo Cat#: 462186 | Name: Tandutinib hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tandutinib hydrochloride is a potent and selective inhibitor of the FLT3 and also inhibits c-Kit and PDGFR. andutinib hydrochloride has the ability to cross the blood-brain barrier.

Chemical Structure

Tandutinib hydrochloride
Tandutinib hydrochloride
CAS#2438900-70-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 462186

Name: Tandutinib hydrochloride

CAS#: 2438900-70-8 (HCl)

Chemical Formula: C31H43ClN6O4

Exact Mass: 598.3034

Molecular Weight: 599.17

Elemental Analysis: C, 62.14; H, 7.23; Cl, 5.92; N, 14.03; O, 10.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
2438900-70-8 (HCl) 387867-13-2 (free base) 387867-14-3 (sulfate)
Synonym
Tandutinib hydrochloride; CT53518 hydrochloride; MLN 518 hydrochloride
IUPAC/Chemical Name
4-[6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide hydrochloride
InChi Key
FOEBHLNUCNUHHJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H42N6O4.ClH/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35;/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38);1H
SMILES Code
O=C(N1CCN(C2=C3C=C(OC)C(OCCCN4CCCCC4)=CC3=NC=N2)CC1)NC5=CC=C(OC(C)C)C=C5.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 599.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kelly LM, Yu JC, Boulton CL, et al. CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML). Cancer Cell. 2002;1(5):421‐432. doi:10.1016/s1535-6108(02)00070-3. 2: Griswold IJ, Shen LJ, La Rosée P, et al. Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesis. Blood. 2004;104(9):2912‐2918. doi:10.1182/blood-2003-05-1669. 3: Yang JJ, Milton MN, Yu S, et al. P-glycoprotein and breast cancer resistance protein affect disposition of tandutinib, a tyrosine kinase inhibitor. Drug Metab Lett. 2010;4(4):201‐212. doi:10.2174/187231210792928279.