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MedKoo Cat#: 534836 | Name: Folpet
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Folpet is a Russian cpd.

Chemical Structure

Folpet
Folpet
CAS#133-07-3

Theoretical Analysis

MedKoo Cat#: 534836

Name: Folpet

CAS#: 133-07-3

Chemical Formula: C9H4Cl3NO2S

Exact Mass: 294.9028

Molecular Weight: 296.55

Elemental Analysis: C, 36.45; H, 1.36; Cl, 35.86; N, 4.72; O, 10.79; S, 10.81

Price and Availability

Size Price Availability Quantity
250mg USD 250.00 Back order
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Related CAS #
No Data
Synonym
Folpet; Faltan; Orthophaltan; Phthaltan; Folpel
IUPAC/Chemical Name
1H-Isoindole-1,3(2H)-dione, 2-((trichloromethyl)thio)-
InChi Key
HKIOYBQGHSTUDB-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H4Cl3NO2S/c10-9(11,12)16-13-7(14)5-3-1-2-4-6(5)8(13)15/h1-4H
SMILES Code
O=C1N(SC(Cl)(Cl)Cl)C(C2=C1C=CC=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 296.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Food Safety Commission of Japan. Folpet (Pesticides). Food Saf (Tokyo). 2017 Jun 30;5(2):67-71. doi: 10.14252/foodsafetyfscj.2017002s. PMID: 32231931; PMCID: PMC6989181. 2: Ge H, Chen L, Su Y, Jin C, Ge RS. Effects of Folpet, Captan, and Captafol on Human Aromatase in JEG-3 Cells. Pharmacology. 2018;102(1-2):81-87. doi: 10.1159/000484171. Epub 2018 Jun 28. PMID: 29953993. 3: Huertas-Pérez JF, Ernest M, Badoud F. Quantification of folpet and phthalimide in tea and herbal infusions by LC- high-resolution MS and GC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2019 Jan;36(1):109-119. doi: 10.1080/19440049.2018.1555379. Epub 2019 Jan 2. PMID: 30601712. 4: Huertas-Pérez JF, Ernest M, Varela J, Badoud F. Quantification of folpet and phthalimide in food by gas chromatography and mass spectrometry: Overcoming potential analytical artefacts. Food Chem. 2018 Sep 15;260:213-220. doi: 10.1016/j.foodchem.2018.04.002. Epub 2018 Apr 3. PMID: 29699665. 5: Gordon E, Cohen SM, Singh P. Folpet-induced short term cytotoxic and proliferative changes in the mouse duodenum. Toxicol Mech Methods. 2012 Jan;22(1):54-9. doi: 10.3109/15376516.2011.593054. Epub 2011 Oct 21. PMID: 22017358. 6: Cohen SM, Gordon EB, Singh P, Arce GT, Nyska A. Carcinogenic mode of action of folpet in mice and evaluation of its relevance to humans. Crit Rev Toxicol. 2010 Jul;40(6):531-45. doi: 10.3109/10408441003742903. PMID: 20521864. 7: Berthet A, Bouchard M, Danuser B. Toxicokinetics of captan and folpet biomarkers in orally exposed volunteers. J Appl Toxicol. 2012 Mar;32(3):194-201. doi: 10.1002/jat.1653. Epub 2011 Mar 5. PMID: 21381057. 8: Arce GT, Gordon EB, Cohen SM, Singh P. Genetic toxicology of folpet and captan. Crit Rev Toxicol. 2010 Jul;40(6):546-74. doi: 10.3109/10408444.2010.481663. PMID: 20569196. 9: Chen K, Mackie JC, Kennedy EM, Dlugogorski BZ. Air pollutants formed in thermal decomposition of folpet fungicide under oxidative conditions. Environ Sci Technol. 2011 Jan 15;45(2):554-60. doi: 10.1021/es102652w. Epub 2010 Dec 1. PMID: 21121660. 10: Heredia-Ortiz R, Berthet A, Bouchard M. Toxicokinetic modeling of folpet fungicide and its ring-biomarkers of exposure in humans. J Appl Toxicol. 2013 Jul;33(7):607-17. doi: 10.1002/jat.1782. Epub 2011 Dec 19. PMID: 22180346. 11: Zainal H, Que Hee SS. Folpet permeation through nitrile gloves. Appl Occup Environ Hyg. 2003 Sep;18(9):658-68. doi: 10.1080/10473220301377. PMID: 12909534. 12: Canal-Raffin M, l'Azou B, Jorly J, Hurtier A, Cambar J, Brochard P. Cytotoxicity of folpet fungicide on human bronchial epithelial cells. Toxicology. 2008 Jul 30;249(2-3):160-6. doi: 10.1016/j.tox.2008.05.003. Epub 2008 May 17. PMID: 18586372. 13: Teisseire H, Couderchet M, Vernet G. Toxic responses and catalase activity of Lemna minor L. Exposed to folpet, copper, and their combination. Ecotoxicol Environ Saf. 1998 Jul;40(3):194-200. doi: 10.1006/eesa.1998.1682. PMID: 9679681. 14: Christen V, Krebs J, Fent K. Fungicides chlorothanolin, azoxystrobin and folpet induce transcriptional alterations in genes encoding enzymes involved in oxidative phosphorylation and metabolism in honey bees (Apis mellifera) at sublethal concentrations. J Hazard Mater. 2019 Sep 5;377:215-226. doi: 10.1016/j.jhazmat.2019.05.056. Epub 2019 May 24. PMID: 31170570. 15: Shinde R, Shiragave P, Lakade A, Thorat P, Banerjee K. Multi-residue analysis of captan, captafol, folpet, and iprodione in cereals using liquid chromatography with tandem mass spectrometry. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2019 Nov;36(11):1688-1695. doi: 10.1080/19440049.2019.1662953. Epub 2019 Sep 19. PMID: 31535952. 16: Berthet A, Berode M, Bouchard M. Gas-chromatography mass-spectrometry determination of phthalic acid in human urine as a biomarker of folpet exposure. Anal Bioanal Chem. 2011 Apr;400(2):493-502. doi: 10.1007/s00216-011-4753-5. Epub 2011 Feb 20. PMID: 21336936. 17: Martins MR, Pereira P, Lima N, Cruz-Morais J. Degradation of metalaxyl and folpet by filamentous fungi isolated from Portuguese (Alentejo) vineyard soils. Arch Environ Contam Toxicol. 2013 Jul;65(1):67-77. doi: 10.1007/s00244-013-9877-5. Epub 2013 Feb 22. PMID: 23430293. 18: Oulkar DP, Shinde R, Khan Z, Organtini K, Leonard S, Banerjee K. Improved analysis of captan, tetrahydrophthalimide, captafol, folpet, phthalimide, and iprodione in fruits and vegetables by liquid chromatography tandem mass spectrometry. Food Chem. 2019 Dec 15;301:125216. doi: 10.1016/j.foodchem.2019.125216. Epub 2019 Jul 23. PMID: 31404804. 19: Barrueco C, de la Peña E. Influence of bacterial growth of the overnight culture on the captan- and folpet-induced reversion in the Ames test. Mutagenesis. 1989 Jan;4(1):1-5. doi: 10.1093/mutage/4.1.1. PMID: 2654546. 20: Berthet A, Bouchard M, Vernez D. Toxicokinetics of captan and folpet biomarkers in dermally exposed volunteers. J Appl Toxicol. 2012 Mar;32(3):202-9. doi: 10.1002/jat.1659. Epub 2011 Mar 5. PMID: 21381058.

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HMR-1426

HMR-1426