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MedKoo Cat#: 534793 | Name: Fosveset

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fosveset, also known as MS 325168A and MS 325 ligand, is a ligant excipient.

Chemical Structure

Fosveset
Fosveset
CAS#193901-91-6

Theoretical Analysis

MedKoo Cat#: 534793

Name: Fosveset

CAS#: 193901-91-6

Chemical Formula: C33H44N3O14P

Exact Mass: 737.2561

Molecular Weight: 737.70

Elemental Analysis: C, 53.73; H, 6.01; N, 5.70; O, 30.36; P, 4.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Fosveset; MS 325 ligand; MS325 ligand; MS-325 ligand; MS 325168A; MS-325168A; MS325168A;
IUPAC/Chemical Name
2-Oxa-6,9-diaza-1-phosphaundecan-11-oic acid, 4-(bis(carboxymethyl)amino)-6,9-bis(carboxymethyl)-1-((4,4-diphenylcyclohexyl)oxy)-1-hydroxy-, 1-oxide
InChi Key
NZLPWFTXPYJYSS-UHFFFAOYSA-N
InChi Code
InChI=1S/C33H44N3O14P/c37-28(38)18-34(15-16-35(19-29(39)40)20-30(41)42)17-26(36(21-31(43)44)22-32(45)46)23-49-51(47,48)50-27-11-13-33(14-12-27,24-7-3-1-4-8-24)25-9-5-2-6-10-25/h1-10,26-27H,11-23H2,(H,37,38)(H,39,40)(H,41,42)(H,43,44)(H,45,46)(H,47,48)
SMILES Code
O=C(O)CN(CC(O)=O)CCN(CC(O)=O)CC(N(CC(O)=O)CC(O)=O)COP(O)(OC1CCC(C2=CC=CC=C2)(C3=CC=CC=C3)CC1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 737.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Maingret F, Patel AJ, Lesage F, Lazdunski M, Honoré E. Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK. J Biol Chem. 2000 Apr 7;275(14):10128-33. doi: 10.1074/jbc.275.14.10128. PMID: 10744694. 2: Klymenko OV, Amatore C, Svir I. Time-dependent diffusion-migration at cylindrical and spherical microelectrodes: steady- and quasi-steady-state analytical solution can be used under transient conditions. Anal Chem. 2007 Aug 15;79(16):6341-7. doi: 10.1021/ac0706168. Epub 2007 Jul 19. PMID: 17637041. 3: McArdle HJ, Danzeisen R, Fosset C, Gambling L. The role of the placenta in iron transfer from mother to fetus and the relationship between iron status and fetal outcome. Biometals. 2003 Mar;16(1):161-7. doi: 10.1023/a:1020714915767. PMID: 12572675. 4: Lazdunski M, Barhanin J, Borsotto M, Cognard C, Cooper C, Coppola T, Fosset M, Galizzi JP, Hosey MM, Mourre C, et al. Molecular properties of structure and regulation of the calcium channel. Ann N Y Acad Sci. 1988;522:134-49. doi: 10.1111/j.1749-6632.1988.tb33350.x. PMID: 2454048. 5: Gambling L, Danzeisen R, Fosset C, Andersen HS, Dunford S, Srai SK, MCArdle HJ. Iron and copper interactions in development and the effect on pregnancy outcome. J Nutr. 2003 May;133(5 Suppl 1):1554S-6S. doi: 10.1093/jn/133.5.1554S. PMID: 12730464. 6: Bernardi H, Bidard JN, Fosset M, Hugues M, Mourre C, Rehm H, Romey G, Schmid- Antomarchi H, Schweitz H, de Weille JR, et al. Molecular properties of potassium channels. Arzneimittelforschung. 1989 Jan;39(1A):159-63. PMID: 2655615. 7: Findlay JK, Breuer H. Influence of an 18-hydroxyl group on the interaction of oestrogens and hydroxysteroid oxidoreductases. Biochem J. 1974 Feb;137(2):273-9. doi: 10.1042/bj1370273. PMID: 4824210; PMCID: PMC1166114. 8: Paris S, Ailhaud G. Amino acid and glucose transport in sarcolemmal vesicles from chick embryo heart. Biochim Biophys Acta. 1980 Oct 2;601(3):630-9. doi: 10.1016/0005-2736(80)90564-7. PMID: 7417441. 9: Fosset FT, Blais MC. Prevalence of feline blood groups in the Montreal area of Quebec, Canada. Can Vet J. 2014 Jan;55(1):1225-8. Erratum in: Can Vet J. 2014 Feb;55(2):106. PMID: 24381340; PMCID: PMC3866853. 10: Lazdunski M, Allard B, Bernardi H, De Weille J, Fosset M, Heurteaux C, Honoré E. ATP-sensitive K+ channels. Ren Physiol Biochem. 1994 May- Aug;17(3-4):118-20. PMID: 7518937. 11: Fosset M, De Weille J, Schmid-Antomarchi H, Bernardi H, Lazdunski M. Identification, mécanismes de fonctionnement et régulation des canaux potassium sensibles à l'ATP cibles des sulfonylurées utilisées dans le traitement du diabète de type II [Identification, function mechanisms and regulation of potassium channels sensitive to ATP which are targets of sulfonylureas used in the treatment of type II diabetes mellitus]. Journ Annu Diabetol Hotel Dieu. 1989:7-11. French. PMID: 2503655. 12: Lazdunski M, Fosset M, Hughes M, Mourre C, Romey G, Schmid-Antomarchi H. The apamin-sensitive Ca2+-dependent K+ channel molecular properties, differentiation and endogenous ligands in mammalian brain. Biochem Soc Symp. 1985;50:31-42. PMID: 2428371. 13: Dia A, Sakho A, Fall B, Diop A. La hernie paraduodenale gauche--à propos d'un cas [A left paraduodenal hernia--a case report]. Dakar Med. 1998;43(2):245-7. French. PMID: 10797975. 14: Lavergne SN, Fosset FT, Kennedy P, Refsal KR. Potential cutaneous hypersensitivity reaction to an inactive ingredient of thyroid hormone supplements in a dog. Vet Dermatol. 2016 Feb;27(1):53-e16. doi: 10.1111/vde.12281. Epub 2015 Dec 21. PMID: 26748887. 15: Fosset M, Jaimovich E, Delpont E, Lazdunski M. [3H]nitrendipine receptors in skeletal muscle. J Biol Chem. 1983 May 25;258(10):6086-92. PMID: 6304026. 16: Fosset C, McGaw BA, Abramovich D, McArdle HJ. Interrelations between ceruloplasmin and Fe status during human pregnancy. Biol Trace Elem Res. 2004 Apr;98(1):1-12. doi: 10.1385/BTER:98:1:01. PMID: 15051895. 17: Maingret F, Fosset M, Lesage F, Lazdunski M, Honoré E. TRAAK is a mammalian neuronal mechano-gated K+ channel. J Biol Chem. 1999 Jan 15;274(3):1381-7. doi: 10.1074/jbc.274.3.1381. PMID: 9880510. 18: Fosset C, Danzeisen R, Gambling L, McGaw BA, McArdle HJ. Cu loading alters expression of non-IRE regulated, but not IRE regulated, Fe dependent proteins in HepG2 cells. J Inorg Biochem. 2009 May;103(5):709-16. doi: 10.1016/j.jinorgbio.2009.01.007. Epub 2009 Jan 22. PMID: 19232737. 19: Renaud JF, Fosset M, Kazazoglou T, Lazdunski M, Schmid A. Appearance and function of voltage-dependent Ca2+ channels during pre- and postnatal development of cardiac and skeletal muscles. Ann N Y Acad Sci. 1989;560:418-25. doi: 10.1111/j.1749-6632.1989.tb24126.x. PMID: 2545149. 20: Fosset C, Chauveau MJ, Guillon B, Canal F, Drapier JC, Bouton C. RNA silencing of mitochondrial m-Nfs1 reduces Fe-S enzyme activity both in mitochondria and cytosol of mammalian cells. J Biol Chem. 2006 Sep 1;281(35):25398-406. doi: 10.1074/jbc.M602979200. Epub 2006 Jun 20. PMID: 16787928.

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