Lipoxygenin | 5-LO Inhibitor

MedKoo Cat#: 574314 | Name: Lipoxygenin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO). It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-β-, activin A-, bone morphogenic protein (BMP)-, or Wnt-dependent signaling in HEK293T cells. Lipoxygenin increases levels of troponin T (TnnT), a marker of cardiomyocyte differentiation, in human induced pluripotent stem cells (iPSCs) stimulated with BMP4 and the glycogen synthase kinase 3 (GSK3) inhibitor CHIR99021.

Chemical Structure

Lipoxygenin

CAS#2247911-68-6

Theoretical Analysis

MedKoo Cat#: 574314

Name: Lipoxygenin

CAS#: 2247911-68-6

Chemical Formula: C24H22N2O4

Exact Mass: 402.1580

Molecular Weight: 402.45

Elemental Analysis: C, 71.63; H, 5.51; N, 6.96; O, 15.90

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 350.00	2 Weeks
10mg	USD 650.00	2 Weeks

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Related CAS #

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Synonym

Lipoxygenin

IUPAC/Chemical Name

naphthalen-2-yl(2',4,6-trimethoxy-[3,3'-bipyridin]-5-yl)methanol

InChi Key

OSVNGDATIGOCLA-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H22N2O4/c1-28-22-19(18-9-6-12-25-23(18)29-2)14-26-24(30-3)20(22)21(27)17-11-10-15-7-4-5-8-16(15)13-17/h4-14,21,27H,1-3H3

SMILES Code

OC(C1=C(OC)C(C2=CC=CN=C2OC)=CN=C1OC)C3=CC=C(C=CC=C4)C4=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

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Product Data

Product Data

Instruction

View handling instruction

Biological target:

Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO).

In vitro activity:

Lipoxygenin is a non-redox 5-LO inhibitor, modulates the β-catenin-5-LO complex and induces reduction of both β-catenin and 5-LO levels in the nucleus. Lipoxygenin and the structurally unrelated 5-LO inhibitor CJ-13,610 promote cardiac differentiation of human induced pluripotent stem cells and inhibit Hedgehog, TGF-β, BMP, and Activin A signaling, suggesting an unexpected and yet unknown role of 5-LO in these developmental pathways. Reference: Cell Chem Biol. 2018 Sep 20;25(9):1095-1106.e23. https://pubmed.ncbi.nlm.nih.gov/30251630/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	30.0	74.54
	DMSO	30.0	74.54
	DMSO:PBS (pH 7.2) (1:1)	0.5	1.24

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 402.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Brand S, Roy S, Schröder P, Rathmer B, Roos J, Kapoor S, Patil S, Pommerenke C, Maier T, Janning P, Eberth S, Steinhilber D, Schade D, Schneider G, Kumar K, Ziegler S, Waldmann H. Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways. Cell Chem Biol. 2018 Sep 20;25(9):1095-1106.e23. doi: 10.1016/j.chembiol.2018.05.016. Epub 2018 Jun 28. PMID: 30251630.

In vitro protocol:

In vivo protocol:

TBD

1. Brand, S., Roy, S., Schröder, P., et al. Combined proteomic and in silico target identification reveal a role for 5-lipoxygenase in developmental signaling pathways. Cell Chem. Biol. 25(9), 1095-1106 (2018).