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MedKoo Cat#: 461626 | Name: Disulfoton
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Disulfoton is an organophosphate insecticide.

Chemical Structure

Disulfoton
Disulfoton
CAS#298-04-4

Theoretical Analysis

MedKoo Cat#: 461626

Name: Disulfoton

CAS#: 298-04-4

Chemical Formula: C8H19O2PS3

Exact Mass: 274.0285

Molecular Weight: 274.39

Elemental Analysis: C, 35.02; H, 6.98; O, 11.66; P, 11.29; S, 35.05

Price and Availability

Size Price Availability Quantity
250mg USD 350.00 2 Weeks
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Related CAS #
No Data
Synonym
Disulfoton; Dithiodemeton; Glebofos; Frumin; Dithiosystox; Solvigran; M-74; M 74; M74; Bayer 19639; Bayer19639; Bayer-19639
IUPAC/Chemical Name
O,O-diethyl S-(2-(ethylthio)ethyl) phosphorodithioate
InChi Key
DOFZAZXDOSGAJZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H19O2PS3/c1-4-9-11(12,10-5-2)14-8-7-13-6-3/h4-8H2,1-3H3
SMILES Code
S=P(OCC)(SCCSCC)OCC
Appearance
Liquid
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Disulfoton is an organophosphate insecticide.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 274.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Usui K, Hayashizaki Y, Minagawa T, Hashiyada M, Nakano A, Funayama M. Rapid determination of disulfoton and its oxidative metabolites in human whole blood and urine using QuEChERS extraction and liquid chromatography-tandem mass spectrometry. Leg Med (Tokyo). 2012 Nov;14(6):309-16. doi: 10.1016/j.legalmed.2012.06.005. Epub 2012 Jul 18. PubMed PMID: 22818267. 2: Futagami K, Otsubo K, Nakao Y, Aoyama T, Iimori E, Urakami S, Ide M, Oishi R. Acute organophosphate poisoning after disulfoton ingestion. J Toxicol Clin Toxicol. 1995;33(2):151-5. PubMed PMID: 7897754. 3: Yashiki M, Kojima T, Ohtani M, Chikasue F, Miyazaki T. Determination of disulfoton and its metabolites in the body fluids of a Di-Syston intoxication case. Forensic Sci Int. 1990 Dec;48(2):145-54. PubMed PMID: 2283138. 4: Gan Q, Jans U. Reaction of thiometon and disulfoton with reduced sulfur species in simulated natural environment. J Agric Food Chem. 2006 Oct 4;54(20):7753-60. PubMed PMID: 17002449. 5: Chapman RA, Tolman JH, Cole C. The effect of multiple soil applications of disulfoton on enhanced microbial degradation in soil and subsequent uptake of insecticidal chemicals by potato plants. J Environ Sci Health B. 1994 May;29(3):485-506. PubMed PMID: 8201175. 6: Costa LG, Murphy SD. Unidirectional cross-tolerance between the carbamate insecticide propoxur and the organophosphate disulfoton in mice. Fundam Appl Toxicol. 1983 Sep-Oct;3(5):483-8. PubMed PMID: 6642106. 7: Szeto SY, Vernon RS, Brown MJ. Degradation of disulfoton in soil and its translocation into asparagus. J Agric Food Chem. 1983 Mar-Apr;31(2):217-20. PubMed PMID: 6853850. 8: Arnold H, Pluta HJ, Braunbeck T. Sublethal effects of prolonged exposure to disulfoton in rainbow trout (Oncorhynchus mykiss): cytological alterations in the liver by a potent acetylcholine esterase inhibitor. Ecotoxicol Environ Saf. 1996 Jun;34(1):43-55. PubMed PMID: 8793319. 9: Schwab BW, Murphy SD. Induction of anticholinesterase tolerance in rats with doses of disulfoton that produce no cholinergic signs. J Toxicol Environ Health. 1981 Jul-Aug;8(1-2):199-204. PubMed PMID: 7328703. 10: Lynch AM, Robinson SA, Wilcox P, Smith MD, Kleinman M, Jiang K, Rees RW. Cycloheximide and disulfoton are positive in the photoclastogencity assay but do not absorb UV irradiation: another example of pseudophotoclastogenicity? Mutagenesis. 2008 Mar;23(2):111-8. doi: 10.1093/mutage/gem053. Epub 2008 Jan 27. PubMed PMID: 18227081. 11: Tanaka Y, Takahashi K, Kirigaya T, Hosoi S, Hidaka T, Kanda H, Nakazawa H. [Analysis of disulfoton sulfoxide in chingentsuai by pulsed splitless mass spectrometry using programmed temperature vaporization (PTV) inlet]. Shokuhin Eiseigaku Zasshi. 2006 Jun;47(3):105-10. Japanese. PubMed PMID: 16862987. 12: Bavili Tabrizi A, Abdollahi A. Determination of Organothiophosphate Insecticides in Environmental Water Samples by a Very Simple and Sensitive Spectrofluorimetric Method. Bull Environ Contam Toxicol. 2015 Oct;95(4):536-41. doi: 10.1007/s00128-015-1612-7. Epub 2015 Jul 26. PubMed PMID: 26210825. 13: Llorens J, Crofton KM, Tilson HA, Ali SF, Mundy WR. Characterization of disulfoton-induced behavioral and neurochemical effects following repeated exposure. Fundam Appl Toxicol. 1993 Feb;20(2):163-9. PubMed PMID: 8449387. 14: Clark G, Pearson DW. Learning in chronic disulfoton poisoning. J Gen Psychol. 1973 Oct;89(2d Half):305-11. PubMed PMID: 4795234. 15: Chapman RA, Harris CR, Tolman JH, Dubois D, Cole C. The persistence of insecticidal chemicals in soils treated with granular formulations of disulfoton and their uptake by potato plants. J Environ Sci Health B. 1994 Mar;29(2):233-45. PubMed PMID: 8169317. 16: Costa LG, Schwab BW, Hand H, Murphy SD. Reduced [3H]quinuclidinyl benzilate binding to muscarinic receptors in disulfoton-tolerant mice. Toxicol Appl Pharmacol. 1981 Sep 30;60(3):441-50. PubMed PMID: 7292482. 17: White DH, Seginak JT. Brain cholinesterase inhibition in songbirds from pecan groves sprayed with phosalone and disulfoton. J Wildl Dis. 1990 Jan;26(1):103-6. PubMed PMID: 2304190. 18: Henderson MC, Krueger SK, Siddens LK, Stevens JF, Williams DE. S-oxygenation of the thioether organophosphate insecticides phorate and disulfoton by human lung flavin-containing monooxygenase 2. Biochem Pharmacol. 2004 Sep 1;68(5):959-67. PubMed PMID: 15294458. 19: Costa LG, Murphy SD. Passive avoidance retention in mice tolerant to the organophosphorus insecticide disulfoton. Toxicol Appl Pharmacol. 1982 Sep 30;65(3):451-8. PubMed PMID: 7157376. 20: Brokopp CD, Wyatt JL, Gabica J. Dialkyl phosphates in urine samples from pesticide formulators exposed to disulfoton and phorate. Bull Environ Contam Toxicol. 1981 Apr;26(4):524-9. PubMed PMID: 7236911.