CAY10744 is a topoisomerase II-α poison. It inhibits topoisomerase II-α by 78.9% when used at a concentration of 20 µM. CAY10744 is selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 µM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells.
MedKoo Cat#: 462126
Name: CAY10744
CAS#: 2375613-31-1
Chemical Formula: C24H16ClNO2
Exact Mass: 385.0870
Molecular Weight: 385.85
Elemental Analysis: Chemical Formula: C24H16ClNO2 Exact Mass: 385.0870 Molecular Weight: 385.8470 Elemental Analysis: C, 74.71; H, 4.18; Cl, 9.19; N, 3.63; O, 8.29
The following data is based on the product molecular weight 385.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
