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MedKoo Cat#: 597732 | Name: Pentagastrin meglumine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pentagastrin meglumine is a synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.

Chemical Structure

Pentagastrin meglumine
Pentagastrin meglumine
CAS#57448-84-7

Theoretical Analysis

MedKoo Cat#: 597732

Name: Pentagastrin meglumine

CAS#: 57448-84-7

Chemical Formula: C44H66N8O14S

Exact Mass:

Molecular Weight: 963.11

Elemental Analysis: C, 54.87; H, 6.91; N, 11.63; O, 23.26; S, 3.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Pentagastrin meglumine;
IUPAC/Chemical Name
(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol (10S,13S,16S)-10-((1H-indol-3-yl)methyl)-16-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-2,2-dimethyl-13-(2-(methylthio)ethyl)-4,8,11,14-tetraoxo-3-oxa-5,9,12,15-tetraazaoctadecan-18-oate
InChi Key
CLQJDCJPAPUNET-PPFXAFMZSA-N
InChi Code
InChI=1S/C37H49N7O9S.C7H17NO5/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22;1-8-2-4(10)6(12)7(13)5(11)3-9/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47);4-13H,2-3H2,1H3/t26-,27-,28-,29-;4-,5+,6+,7+/m00/s1
SMILES Code
O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC.O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC([C@H](CCSC)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(CCNC(OC(C)(C)C)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 963.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Webb JK, Rupniak NM, Boyce S. Inhibition of pentagastrin-induced pressor response in conscious rats by the CCK-B receptor antagonist CI-988 and chlordiazepoxide. Regul Pept. 1996 Jan 16;61(1):71-6. PubMed PMID: 8701030. 2: Frankland PW, Josselyn SA, Bradwejn J, Vaccarino FJ, Yeomans JS. Activation of amygdala cholecystokininB receptors potentiates the acoustic startle response in the rat. J Neurosci. 1997 Mar 1;17(5):1838-47. PubMed PMID: 9030642. 3: Pinnock RD, Suman-Chauhan N, Daum P, Hill DR, Woodruff GN. The cholecystokinin-induced increase in intracellular calcium in AR42J cells is mediated by CCKB receptors linked to internal calcium stores. Neuropeptides. 1994 Sep;27(3):175-83. PubMed PMID: 7816188. 4: Gaw AJ, Hills DM, Spraggs CF. Characterization of the receptors and mechanisms involved in the cardiovascular actions of sCCK-8 in the pithed rat. Br J Pharmacol. 1995 Jun;115(4):660-4. PubMed PMID: 7582487; PubMed Central PMCID: PMC1908495. 5: Singh L, Field MJ, Hughes J, Menzies R, Oles RJ, Vass CA, Woodruff GN. The behavioural properties of CI-988, a selective cholecystokininB receptor antagonist. Br J Pharmacol. 1991 Sep;104(1):239-45. PubMed PMID: 1686205; PubMed Central PMCID: PMC1908271. 6: Singh L, Lewis AS, Field MJ, Hughes J, Woodruff GN. Evidence for an involvement of the brain cholecystokinin B receptor in anxiety. Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1130-3. PubMed PMID: 1996314; PubMed Central PMCID: PMC50970. 7: Nishida A, Miyata K, Tsutsumi R, Yuki H, Akuzawa S, Kobayashi A, Kamato T, Ito H, Yamano M, Katuyama Y, et al. Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo. J Pharmacol Exp Ther. 1994 May;269(2):725-31. PubMed PMID: 7910212. 8: Thjodleifsson B, Wormsley KG. Response to pentagastrin in man. III. Comparison of two formulations. Acta Hepatogastroenterol (Stuttg). 1975 Aug;22(4):256-63. PubMed PMID: 1101601. 9: Weng JH, Blommaert AG, Moizo L, Bado A, Ducos B, Böhme A, Garbay C, Roques BP. Role of N- and C-terminal substituents on the CCK-B agonist-antagonist pharmacological profile of Boc-Trp-Phg-Asp-Nal-NH2 derivatives. Bioorg Med Chem. 1996 Apr;4(4):563-73. PubMed PMID: 8735845. 10: Harper EA, Shankley NP, Black JW. Characterization of the binding of a novel radioligand to CCKB/gastrin receptors in membranes from rat cerebral cortex. Br J Pharmacol. 1999 Mar;126(6):1504-12. PubMed PMID: 10217546; PubMed Central PMCID: PMC1565918. 11: Hayward NJ, Harding M, Lloyd SA, McKnight AT, Hughes J, Woodruff GN. The effect of CCKB/gastrin antagonists on stimulated gastric acid secretion in the anaesthetized rat. Br J Pharmacol. 1991 Dec;104(4):973-7. PubMed PMID: 1687371; PubMed Central PMCID: PMC1908834. 12: Boyle SJ, Tang KW, Woodruff GN, McKnight AT. Characterization of CCK receptors in a novel smooth muscle preparation from the guinea-pig stomach by use of the selective antagonists CI-988, L-365,260 and devazepide. Br J Pharmacol. 1993 Aug;109(4):913-7. PubMed PMID: 8401944; PubMed Central PMCID: PMC2175762. 13: Attoub S, Moizo L, Laigneau JP, Alchepo B, Lewin MJ, Bado A. YM022, a highly potent and selective CCKB antagonist inhibiting gastric acid secretion in the rat, the cat and isolated rabbit glands. Fundam Clin Pharmacol. 1998;12(3):256-62. PubMed PMID: 9646057.

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