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MedKoo Cat#: 462116 | Name: MIT-PZR
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MIT-PZR is a mitochondria-targeted fluorescent probe. It is aggregation-induced emission (AIE) active. MIT-PZR can be used in live cells and in vivo.

Chemical Structure

MIT-PZR
MIT-PZR
CAS#2376848-06-3

Theoretical Analysis

MedKoo Cat#: 462116

Name: MIT-PZR

CAS#: 2376848-06-3

Chemical Formula: C33H30N4OS2

Exact Mass: 562.1861

Molecular Weight: 562.75

Elemental Analysis: C, 70.43; H, 5.37; N, 9.96; O, 2.84; S, 11.39

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
5mg USD 900.00 2 Weeks
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Related CAS #
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Synonym
MIT-PZR
IUPAC/Chemical Name
2-[5-[[10-(2-ethylhexyl)-10H-phenothiazin-3-yl]methylene]-4-oxo-3-phenyl-2-thiazolidinylidene]-propanedinitrile
InChi Key
InChi Code
InChI=1S/C33H30N4OS2/c1-3-5-11-23(4-2)22-36-27-14-9-10-15-29(27)39-30-18-24(16-17-28(30)36)19-31-32(38)37(26-12-7-6-8-13-26)33(40-31)25(20-34)21-35/h6-10,12-19,23H,3-5,11,22H2,1-2H3/b31-19-
SMILES Code
O=C(N(C1=CC=CC=C1)/C(S/2)=C(C#N)/C#N)C2=C\C(C=C3)=CC4=C3N(CC(CC)CCCC)C5=CC=CC=C5S4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
MIT-PZR is a mitochondria-targeted fluorescent probe.
In vitro activity:
In this study, using rhodamine as the acceptor and phenothiazine as the donor, this study synthesized a novel mitochondrial-targeted near infrared (NIR) fluorescent probe, MIT-PZR. Due to low cytotoxicity, great photostability and high specificity for mitochondria targeting, MIT-PZR has enormous potential for cell imaging. Furthermore, with a sizeable Stokes shift (emission peak at 705 nm), MIT-PZR penetrated tissues providing stable red fluorescence for imaging in vivo. Reference: Spectrochim Acta A Mol Biomol Spectrosc. 2020 Jan 5;224:117456. https://pubmed.ncbi.nlm.nih.gov/31419747/
In vivo activity:
In this study, using rhodamine as the acceptor and phenothiazine as the donor, this study synthesized a novel mitochondrial-targeted near infrared (NIR) fluorescent probe, MIT-PZR. Due to low cytotoxicity, great photostability and high specificity for mitochondria targeting, MIT-PZR has enormous potential for cell imaging. Furthermore, with a sizeable Stokes shift (emission peak at 705 nm), MIT-PZR penetrated tissues providing stable red fluorescence for imaging in vivo. Reference: Spectrochim Acta A Mol Biomol Spectrosc. 2020 Jan 5;224:117456. https://pubmed.ncbi.nlm.nih.gov/31419747/
Solvent mg/mL mM comments
Solubility
DMF 30.0 53.31
DMSO 30.0 53.31
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 562.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
Dong Y, Chen Z, Hou M, Qi L, Yan C, Lu X, Liu R, Xu Y. Mitochondria-targeted aggregation-induced emission active near infrared fluorescent probe for real-time imaging. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Jan 5;224:117456. doi: 10.1016/j.saa.2019.117456. Epub 2019 Aug 6. PMID: 31419747.
In vitro protocol:
Dong Y, Chen Z, Hou M, Qi L, Yan C, Lu X, Liu R, Xu Y. Mitochondria-targeted aggregation-induced emission active near infrared fluorescent probe for real-time imaging. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Jan 5;224:117456. doi: 10.1016/j.saa.2019.117456. Epub 2019 Aug 6. PMID: 31419747.
In vivo protocol:
Dong Y, Chen Z, Hou M, Qi L, Yan C, Lu X, Liu R, Xu Y. Mitochondria-targeted aggregation-induced emission active near infrared fluorescent probe for real-time imaging. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Jan 5;224:117456. doi: 10.1016/j.saa.2019.117456. Epub 2019 Aug 6. PMID: 31419747.
1: Dong, Y., Chen, Z., Hou, L., et al. Mitochondria-targeted aggregation-induced emission active near infrared fluorescent probe for real-time imaging. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 224, 117456 (2019).