Synonym
Succinylsulfathiazole; NSC 14193; Succinilsolfatiazolo; Sulfadigesin; Colistatin; Kaoxidine; Sulfasuxidine
IUPAC/Chemical Name
4'-(2-Thiazolylsulfamoyl)succinanilic acid
InChi Key
SKVLYVHULOWXTD-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H13N3O5S2/c17-11(5-6-12(18)19)15-9-1-3-10(4-2-9)23(20,21)16-13-14-7-8-22-13/h1-4,7-8H,5-6H2,(H,14,16)(H,15,17)(H,18,19)
SMILES Code
O=C(NC1=CC=C(S(NC2=NC=CS2)(=O)=O)C=C1)CCC(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Succinylsulfathiazole is an antimicrobial agent.
In vitro activity:
To be determined
In vivo activity:
Succinylsulfathiazole can modulate critical energy and nutrient sensing pathways converging onto mTOR signaling, and potentially confounding cancer studies. In c57Bl/6 male mice fed folate supplemented and deficient diets, there was not any significant difference on growth and weight gain at 21 weeks. Succinylsulfathiazole did not significantly affect folate levels in the plasma, liver and colon tissues. However, it did alter energy metabolism and expression of key genes in the mTOR signaling pathway in the liver.
Reference: Exp Gerontol. 2021 Jul 15;150:111387. https://pubmed.ncbi.nlm.nih.gov/33957263/
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMSO |
100.0 |
281.38 |
| Water |
1.0 |
2.81 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
355.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
1. Beydoun S, Fardous AM, Saruna MM, Beydoun AG, Sorge JA, Ma H, Aoun G, Unnikrishnan A, Cabelof DC, Heydari AR. Succinylsulfathiazole modulates the mTOR signaling pathway in the liver of c57BL/6 mice via a folate independent mechanism. Exp Gerontol. 2021 Jul 15;150:111387. doi: 10.1016/j.exger.2021.111387. Epub 2021 May 3. PMID: 33957263; PMCID: PMC8165018.
2. Xia J, Tian H, Chen J, Lin L, Guo Z, Han B, Yang H, Feng Z. pH-Triggered Sheddable Shielding System for Polycationic Gene Carriers. Polymers (Basel). 2016 Apr 14;8(4):141. doi: 10.3390/polym8040141. PMID: 30979234; PMCID: PMC6432142.
In vitro protocol:
To be determined
In vivo protocol:
1. Beydoun S, Fardous AM, Saruna MM, Beydoun AG, Sorge JA, Ma H, Aoun G, Unnikrishnan A, Cabelof DC, Heydari AR. Succinylsulfathiazole modulates the mTOR signaling pathway in the liver of c57BL/6 mice via a folate independent mechanism. Exp Gerontol. 2021 Jul 15;150:111387. doi: 10.1016/j.exger.2021.111387. Epub 2021 May 3. PMID: 33957263; PMCID: PMC8165018.
2. Xia J, Tian H, Chen J, Lin L, Guo Z, Han B, Yang H, Feng Z. pH-Triggered Sheddable Shielding System for Polycationic Gene Carriers. Polymers (Basel). 2016 Apr 14;8(4):141. doi: 10.3390/polym8040141. PMID: 30979234; PMCID: PMC6432142.
1: Maternal gut and fetal brain connection: Increased anxiety and reduced social interactions in Wistar rat offspring following peri conceptional antibiotic exposure Stéphanie Degroote, Darel J. Hunting, Andrea A. Baccarelli, Larissa Takser Prog Neuropsychopharmacol Biol Psychiatry. Author manuscript; available in PMC 2019 Jun 20.Published in final edited form as: Prog Neuropsychopharmacol Biol Psychiatry. 2016 Nov 3; 71: 76–82. Published online 2016 Jun 21. doi: 10.1016/j.pnpbp.2016.06.010 PMCID: PMC6584952
2: The Effect of Several Compounds on the Inhibition of Bacterial Growth by Sulfaguanidine, Sulfamerazine, and Sulfasuxidine William E. Clapper, Ikuya T. Kurita J Bacteriol. 1948 Feb; 55(2): 277–284. PMCID: PMC518437
3: Murine Methyl Donor Deficiency Impairs Early Growth in Association with Dysmorphic Small Intestinal Crypts and Reduced Gut Microbial Community Diversity Antonio V Alves da Silva, Stephanie B de Castro Oliveira, Sara C Di Rienzi, Kathleen Brown Steinke, Lauren M Dehan, Jill K Rood, Vinicius S Carreira, Hung Le, Elizabeth A Maier, Kristina J Betz, Eitaro Aihara, Ruth E Ley, Geoffrey A Preidis, Lanlan Shen, Sean R Moore Curr Dev Nutr. 2019 Jan; 3(1): nzy070. Published online 2018 Oct 3. doi: 10.1093/cdn/nzy070 PMCID: PMC6324351
