Synonym
Iocetamic acid; MP-620; MP 620; MP620
IUPAC/Chemical Name
Propanoic acid, 3-(acetyl(3-amino-2,4,6-triiodophenyl)amino)-2-methyl-
InChi Key
GSVQIUGOUKJHRC-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H13I3N2O3/c1-5(12(19)20)4-17(6(2)18)11-8(14)3-7(13)10(16)9(11)15/h3,5H,4,16H2,1-2H3,(H,19,20)
SMILES Code
O=C(O)C(C)CN(C(C)=O)C1=C(I)C=C(I)C(N)=C1I
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
613.96
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Staubus AE, Berk RN, Loeb PM, Barnhart JL. Saturation kinetics of iocetamic acid: Evaluation of indirect pharmacokinetic techniques and comparison with iopanoic acid. Invest Radiol. 1978 Jan-Feb;13(1):85-92. doi: 10.1097/00004424-197801000-00017. PMID: 147248.
2: Barnhart JL, Berk RN, Czuleger PC. Biliary excretion of three cholecystographic contrast agents in dogs: iocetamic acid, iopronic acid and iosumetic acid. Invest Radiol. 1979 Jan-Feb;14(1):79-87. doi: 10.1097/00004424-197901000-00013. PMID: 158000.
3: Cheng KT. Sodium-2-[(3-butanoylamino-2,4,6-triiodo-phenyl)methyl]butanoate. 2005 Oct 5 [updated 2008 Jun 30]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641974.
4: Fielding JA, Whitehouse GH. A comparative trial of two oral cholecystographic contrast media--iocetamic acid (Cholebrin) and iopanoic acid (Telepaque). Clin Radiol. 1979 Jan;30(1):45-8. doi: 10.1016/s0009-9260(79)80041-0. PMID: 154372.
5: Owen JP, Lavelle MI. Comparative study of iocetamic acid and calcium ipodate in the visualisation of the gallbladder and common bile duct. Clin Radiol. 1978 Sep;29(5):535-40. doi: 10.1016/s0009-9260(78)80046-4. PMID: 152180.
6: Janbroers JM, Sanders JC, Til HP, Feron VJ, De Groot AP. Toxicologic studies of iocetamic acid in rats and dogs. Toxicol Appl Pharmacol. 1969 Mar;14(2):242-8. doi: 10.1016/0041-008x(69)90104-5. PMID: 5772847.
7: Ozsoylu S. Severe thrombocytopenia following oral cholecystography with iocetamic acid. Am J Hematol. 1984 Jan;16(1):103. doi: 10.1002/ajh.2830160115. PMID: 6230004.
8: Janbroers JM, Sanders JC, Til HP, Feron VJ, De Groot AP. Toxicologic and pharmacologic properties of iocetamic acid, a new oral cholecystographic agent. Toxicol Appl Pharmacol. 1969 Mar;14(2):232-41. doi: 10.1016/0041-008x(69)90103-3. PMID: 5772846.
9: Hekster RE. Results obtained in comparative radiographie, clinical and clinical-chemical studies in iocetamic acid (DRC 1201) and iopanoic acid. Radiol Clin Biol. 1968;37(6):338-52. PMID: 5714064.
10: Cargill A, Hately W. A comparative trial of three oral cholecystographic contrast media--iocetamic acid, iopanoic acid and sodium ipodate. Br J Radiol. 1981 Jan;54(637):79-80. doi: 10.1259/0007-1285-54-637-79. PMID: 6449974.
