Synonym
Tefludazine; Lu 18-012; Tefludazinum; Tefludazina
IUPAC/Chemical Name
trans-4-(3-(p-Fluorophenyl)-6-(trifluoromethyl)-1-indanyl)-1-piperazineethanol
InChi Key
JSBWGXQXCRYYTG-CTNGQTDRSA-N
InChi Code
InChI=1S/C22H24F4N2O/c23-17-4-1-15(2-5-17)19-14-21(28-9-7-27(8-10-28)11-12-29)20-13-16(22(24,25)26)3-6-18(19)20/h1-6,13,19,21,29H,7-12,14H2/t19-,21+/m1/s1
SMILES Code
OCCN1CCN([C@H]2C[C@H](C3=CC=C(F)C=C3)C4=C2C=C(C(F)(F)F)C=C4)CC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
408.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Antipsychotics for treatment of delirium in hospitalised non‐ICU patients Lisa Burry, Sangeeta Mehta, Marc M Perreault, Jay S Luxenberg, Najma Siddiqi, Brian Hutton, Dean A Fergusson, Chaim Bell, Louise Rose Cochrane Database Syst Rev. 2018 Jun; 2018(6): CD005594. Published online 2018 Jun 18. doi: 10.1002/14651858.CD005594.pub3 PMCID: PMC6513380
2: Behavioral Evidence of Depolarization Block of Dopamine Neurons after Chronic Treatment with Haloperidol and Clozapine Sandra M. Boye, Pierre-Paul Rompré J Neurosci. 2000 Feb 1; 20(3): 1229–1239. doi: 10.1523/JNEUROSCI.20-03-01229.2000
PMCID: PMC6774188
3: Inhibition of Dengue Virus Replication by a Class of Small-Molecule Compounds That Antagonize Dopamine Receptor D4 and Downstream Mitogen-Activated Protein Kinase Signaling
Jessica L. Smith, David A. Stein, David Shum, Matthew A. Fischer, Constantin Radu, Bhavneet Bhinder, Hakim Djaballah, Jay A. Nelson, Klaus Früh, Alec J. Hirsch
J Virol. 2014 May; 88(10): 5533–5542. doi: 10.1128/JVI.00365-14
PMCID: PMC4019099
4: How antipsychotics work—From receptors to reality
Shitij Kapur, Ofer Agid, Romina Mizrahi, Ming Li
NeuroRx. 2006 Jan; 3(1): 10–21. Published online 2012 Sep 5. doi: 10.1016/j.nurx.2005.12.003
PMCID: PMC3593357
5: Comparison between the pharmacology of dopamine receptors mediating the inhibition of cell firing in rat brain slices through the substantia nigra pars compacta and ventral tegmental area.
B. Bowery, L. A. Rothwell, G. R. Seabrook
Br J Pharmacol. 1994 Jul; 112(3): 873–880. doi: 10.1111/j.1476-5381.1994.tb13161.x
PMCID: PMC1910205
