Synonym
Teclozan; Falmonox; Teclosine; Teclozine; NSC 107433; Teclosan; Teclosine; Win 13146; Win-13146; Win13146; Win-AM 13146;
IUPAC/Chemical Name
Acetamide, N,N'-(1,4-phenylenebis(methylene))bis(2,2-dichloro-N-(2-ethoxyethyl)-
InChi Key
MSJLJWCAEPENBL-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H28Cl4N2O4/c1-3-29-11-9-25(19(27)17(21)22)13-15-5-7-16(8-6-15)14-26(10-12-30-4-2)20(28)18(23)24/h5-8,17-18H,3-4,9-14H2,1-2H3
SMILES Code
O=C(N(CC1=CC=C(CN(CCOCC)C(C(Cl)Cl)=O)C=C1)CCOCC)C(Cl)Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Teclozan (WIN 13146) is an antiprotozoal agent that intervenes in the phospholipid metabolism, preventing the formation of arachidonic acid.
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMSO |
62.5 |
124.44 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
502.25
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1: Kasturi G, Adler RA. The extent of diagnosis and treatment of osteoporosis in a Veterans Affairs population undergoing vertebral augmentation. PM R. 2010 Sep;2(9):811-6. doi: 10.1016/j.pmrj.2010.05.012. PMID: 20869679.
2: Slighter RG, Yarinsky A, Drobeck HP, Bailey DM. Activity of quinfamide against natural infections of Entamoeba criceti in hamsters: a new potent agent for intestinal amoebiasis. Parasitology. 1980 Aug;81(1):157-68. doi: 10.1017/s0031182000055128. PMID: 6252530.
3: Guevara L. Evaluación de la tolerancia y eficacia en humanos de quinfamide un nuevo amebicida intraluminal (tratamiento de un día). Estudio doble ciego [Evaluation of the tolerance and efficiency of quinfamide, a new intraluminal amebicide, in man (one day treatment). Double blind study]. Rev Gastroenterol Mex. 1980 Apr-Jun;45(2):93-7. Spanish. PMID: 7403767.
4: Matuszak J, Gajda B. Ocena kliniczna preparatu Falmonox w leczeniu pełzakowicy [Clinical evaluation of a new amebicide, Falmonox]. Pol Tyg Lek. 1978 Sep 25;33(39):1547-8. Polish. PMID: 704457.
5: Huggins D, Martis CS. Tratamento da amebíase intestinal crónica com dose única de Teclozan [Treatment of chronic intestinal amebiasis with a single dose of teclozan]. An Inst Hig Med Trop (Lisb). 1977-1978;5(1-4):325-7. Portuguese. PMID: 553463.
6: Huggins D. Ensaio clínico com teclozan no tratamento da colite amebiana não desintérica na dose de 24 horas [Clinical test with teclozan in the treatment of amebic dysentery with a dose of 24 hours]. An Inst Hig Med Trop (Lisb). 1977-1978;5(1-4):329-31. Portuguese. PMID: 399824.
7: Atías A, Sapunar J, Parodi V, Pérez C, Gabor M, Stagno S, Subiabre V, Galdames M. Tratamiento de la amibiasis intestinal crónica con teclozán [Treatment of intestinal amebiasis with Teclozan]. Bol Chil Parasitol. 1972 Jul- Dec;27(3):119-21. Spanish. PMID: 4662192.
8: Villafañe HA, Cafferata E, Torrecilla A, Parodi H. Amebiasis: su tratamiento con WIN 13.146 (teclozán [Amebiasis: its treatment with WIN 13.146 (Teclozan)]. Prensa Med Argent. 1972 Jan 21;59(3):124-6. Spanish. PMID: 5019353.
9: Huggins D. Tratamento intensivo da amebíase intestinal crónica. Resultados obtidos com o WIN-13.146 (Tecloxan [Intensive treatment of chronic intestinal amebiasis. Results obtained with WIN-13.146 (Teclozan)]. An Esc Nacl Saude Publica Med Trop (Lisb). 1971 Jan-Jun;5(1):29-31. Portuguese. PMID: 5138868.
10: Machado JO, de Pinho AL. Avaliação de nôvo esquema terapêutico do WIN-13.146 (Teclosan-Falmonox) [Evaluation of a new therapeutic schedule of WIN-13,146 (Teclozan-Falmonox)]. Hospital (Rio J). 1970 Oct;78(4):1091-100. Portuguese. PMID: 5313674.
11: Huggins D. Tratamento intensivo da amebíase intestinal crônica como o WIN-13.146 (Teclozan). Aplicação da dose total em três dias [Intensive treatment of chronic intestinal amebiasis with WIN-13.146 (Teclozan). Application of the total dosage in 3 days]. Hospital (Rio J). 1970 Jul;78(1):235-9. Portuguese. PMID: 5312441.
12: Cariry NA, da Silva MA. Tratamento da amebíase intestinal com Teclozan (Falmonox). Estudo comparativo de esquemas terapêuticos [Treatment of intestinal amebiasis with Teclozan (Falmonox). Comparative study of therapeutic schemes]. Hospital (Rio J). 1969 Sep;76(3):1033-7. Portuguese. PMID: 5313921.
13: Daher HR. Amebíase intestinal. Terapêutica de duração reduzida com o Teclozan [Intestinal amebiasis. Short period therapy using Teclozan]. Hospital (Rio J). 1969 Mar;75(3):879-84. Portuguese. PMID: 5306254.
14: Pádua Mde A. Tratamento da amebíase intestinal pelo Teclosan [Treatment of intestinal amebiasis using Teclozan]. Hospital (Rio J). 1968 Aug;74(2):489-93. Portuguese. PMID: 5308674.
15: PESSOA AV. WIN-AM-13 146 (FALMONOX) NA AMEB'IASE INTESTINAL [WIN-AM-13146 (FALMONOX) IN INTESTINAL AMEBIASIS]. Hospital (Rio J). 1964 Nov;66:969-76. Portuguese. PMID: 14229929.
16: TEIXEIRA R, PORTO G. RESULTADOS OBTIDOS COM O WIN-13.146 (TECLOZINE) EM PACIENTES COM A FORMA CR ONICA DE AMEBIASE INTESTINAL [RESULTS OBTAINED WITH WIN-13146 (TECLOZINE) IN PATIENTS WITH THE CHRONIC FORM OF INTESTINAL AMEBIASIS]. Hospital (Rio J). 1964 Nov;66:1119-21. Portuguese. PMID: 14229922.
17: LEAO VC, SIQUEIRA MW. NOTA PR'EVIA S OBRE A ATIVIDADE ANTIAMEBIANA DO TECLOSAN (WIN-13.146) [PRELIMINARY NOTE ON THE ANTI-AMEBIC ACTIVITY OF TECLOSAN (WIN-13.146)]. Hospital (Rio J). 1964 Jul;66:143-6. Portuguese. PMID: 14181566.
18: GONCALVES RR, MILLER O. [Anti-amebic activity of N, N-bis(dichloroacetyl)-N,N-bis(2-ethoxyethyl)-1,4-bis(aminoethyl)benzene, WIN 13146 (Teclozan)]. Hospital (Rio J). 1963 Jun;63:1305-14. Portuguese. PMID: 13960673.
19: SIMAS AM, FERREIRA HL. [Preliminary note on the action of Win-Am-13146 (Teclosine) in intestinal amebiasis. Clinico-therapeutic trial of a new amebicide]. Hospital (Rio J). 1962 Dec;62:1343-8. Portuguese. PMID: 13992986.
