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MedKoo Cat#: 328063 | Name: Triclosan
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis.Triclosan, similar in its uses and mechanism of action to triclocarban, is an antibacterial and antifungal agent found in consumer products, including toothpaste, soaps, detergents, toys, and surgical cleaning treatments. Its efficacy as an antimicrobial agent, the risk of antimicrobial resistance, and its possible role in disrupted hormonal development remain controversial.

Chemical Structure

Triclosan
Triclosan
CAS#3380-34-5

Theoretical Analysis

MedKoo Cat#: 328063

Name: Triclosan

CAS#: 3380-34-5

Chemical Formula: C12H7Cl3O2

Exact Mass: 287.9512

Molecular Weight: 289.54

Elemental Analysis: C, 49.78; H, 2.44; Cl, 36.73; O, 11.05

Price and Availability

Size Price Availability Quantity
25g USD 265.00 2 Weeks
100g USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
Triclosan
IUPAC/Chemical Name
2,4,4'-Trichloro-2'-hydroxy diphenyl ether
InChi Key
XEFQLINVKFYRCS-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H
SMILES Code
OC1=CC(Cl)=CC=C1OC2=CC=C(Cl)C=C2Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
View CoA: current batch, Lot# T21C12I03
Safety Data Sheet (SDS)
View Safety Data Sheet (SDS)
Instruction
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 289.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Olaniyan LW, Mkwetshana N, Okoh AI. Triclosan in water, implications for human and environmental health. Springerplus. 2016 Sep 21;5(1):1639. Review. PubMed PMID: 27722057; PubMed Central PMCID: PMC5031584. 2: Huang CL, Abass OK, Yu CP. Triclosan: A review on systematic risk assessment and control from the perspective of substance flow analysis. Sci Total Environ. 2016 Oct 1;566-567:771-85. doi: 10.1016/j.scitotenv.2016.05.002. Review. PubMed PMID: 27239720. 3: Guo J, Pan LH, Li YX, Yang XD, Li LQ, Zhang CY, Zhong JH. Efficacy of triclosan-coated sutures for reducing risk of surgical site infection in adults: a meta-analysis of randomized clinical trials. J Surg Res. 2016 Mar;201(1):105-17. doi: 10.1016/j.jss.2015.10.015. Review. PubMed PMID: 26850191. 4: Yueh MF, Tukey RH. Triclosan: A Widespread Environmental Toxicant with Many Biological Effects. Annu Rev Pharmacol Toxicol. 2016;56:251-72. doi: 10.1146/annurev-pharmtox-010715-103417. Review. PubMed PMID: 26738475; PubMed Central PMCID: PMC4774862. 5: Yuan M, Bai MZ, Huang XF, Zhang Y, Liu J, Hu MH, Zheng WQ, Jin F. Preimplantation Exposure to Bisphenol A and Triclosan May Lead to Implantation Failure in Humans. Biomed Res Int. 2015;2015:184845. doi: 10.1155/2015/184845. Review. PubMed PMID: 26357649; PubMed Central PMCID: PMC4556842. 6: Wang CF, Tian Y. Reproductive endocrine-disrupting effects of triclosan: Population exposure, present evidence and potential mechanisms. Environ Pollut. 2015 Nov;206:195-201. doi: 10.1016/j.envpol.2015.07.001. Review. PubMed PMID: 26184583. 7: Dhillon GS, Kaur S, Pulicharla R, Brar SK, Cledón M, Verma M, Surampalli RY. Triclosan: current status, occurrence, environmental risks and bioaccumulation potential. Int J Environ Res Public Health. 2015 May 22;12(5):5657-84. doi: 10.3390/ijerph120505657. Review. PubMed PMID: 26006133; PubMed Central PMCID: PMC4454990. 8: Giuliano CA, Rybak MJ. Efficacy of triclosan as an antimicrobial hand soap and its potential impact on antimicrobial resistance: a focused review. Pharmacotherapy. 2015 Mar;35(3):328-36. doi: 10.1002/phar.1553. Review. PubMed PMID: 25809180. 9: Apisarnthanarak A, Singh N, Bandong AN, Madriaga G. Triclosan-coated sutures reduce the risk of surgical site infections: a systematic review and meta-analysis. Infect Control Hosp Epidemiol. 2015 Feb;36(2):169-79. doi: 10.1017/ice.2014.22. Review. PubMed PMID: 25632999. 10: Roberts J, Price OR, Bettles N, Rendal C, van Egmond R. Accounting for dissociation and photolysis: a review of the algal toxicity of triclosan. Environ Toxicol Chem. 2014 Nov;33(11):2551-9. doi: 10.1002/etc.2710. Review. PubMed PMID: 25099165. 11: Sälzer S, Slot DE, Dörfer CE, Van der Weijden GA. Comparison of triclosan and stannous fluoride dentifrices on parameters of gingival inflammation and plaque scores: a systematic review and meta-analysis. Int J Dent Hyg. 2015 Feb;13(1):1-17. doi: 10.1111/idh.12072. Review. PubMed PMID: 24945592. 12: Witorsch RJ. Critical analysis of endocrine disruptive activity of triclosan and its relevance to human exposure through the use of personal care products. Crit Rev Toxicol. 2014 Jul;44(6):535-55. doi: 10.3109/10408444.2014.910754. Review. PubMed PMID: 24897554. 13: Daoud FC, Edmiston CE Jr, Leaper D. Meta-analysis of prevention of surgical site infections following incision closure with triclosan-coated sutures: robustness to new evidence. Surg Infect (Larchmt). 2014 Jun;15(3):165-81. doi: 10.1089/sur.2013.177. Review. PubMed PMID: 24738988; PubMed Central PMCID: PMC4063374. 14: Dinwiddie MT, Terry PD, Chen J. Recent evidence regarding triclosan and cancer risk. Int J Environ Res Public Health. 2014 Feb 21;11(2):2209-17. doi: 10.3390/ijerph110202209. Review. PubMed PMID: 24566048; PubMed Central PMCID: PMC3945593. 15: Riley P, Lamont T. Triclosan/copolymer containing toothpastes for oral health. Cochrane Database Syst Rev. 2013 Dec 5;(12):CD010514. doi: 10.1002/14651858.CD010514.pub2. Review. PubMed PMID: 24310847. 16: Trombelli L, Farina R. Efficacy of triclosan-based toothpastes in the prevention and treatment of plaque-induced periodontal and peri-implant diseases. Minerva Stomatol. 2013 Mar;62(3):71-88. Review. English, Italian. PubMed PMID: 23518778. 17: Wang ZX, Jiang CP, Cao Y, Ding YT. Systematic review and meta-analysis of triclosan-coated sutures for the prevention of surgical-site infection. Br J Surg. 2013 Mar;100(4):465-73. doi: 10.1002/bjs.9062. Review. PubMed PMID: 23338685. 18: Chang WK, Srinivasa S, Morton R, Hill AG. Triclosan-impregnated sutures to decrease surgical site infections: systematic review and meta-analysis of randomized trials. Ann Surg. 2012 May;255(5):854-9. doi: 10.1097/SLA.0b013e31824e7005. Review. PubMed PMID: 22470067. 19: Bedoux G, Roig B, Thomas O, Dupont V, Le Bot B. Occurrence and toxicity of antimicrobial triclosan and by-products in the environment. Environ Sci Pollut Res Int. 2012 May;19(4):1044-65. doi: 10.1007/s11356-011-0632-z. Review. PubMed PMID: 22057832. 20: Leaper D, Assadian O, Hubner NO, McBain A, Barbolt T, Rothenburger S, Wilson P. Antimicrobial sutures and prevention of surgical site infection: assessment of the safety of the antiseptic triclosan. Int Wound J. 2011 Dec;8(6):556-66. doi: 10.1111/j.1742-481X.2011.00841.x. Review. PubMed PMID: 21854548.

View History

GS-8374

GS-8374