Synonym
Iothalamate sodium; Conray 400; Conray-400; Conray400; Mediocontrix
IUPAC/Chemical Name
5-Acetylamino-N-methyl-2,4,6-triiodoisophthalamic acid sodium salt
InChi Key
WCIMWHNSWLLELS-UHFFFAOYSA-M
InChi Code
InChI=1S/C11H9I3N2O4.Na/c1-3(17)16-9-7(13)4(10(18)15-2)6(12)5(8(9)14)11(19)20;/h1-2H3,(H,15,18)(H,16,17)(H,19,20);/q;+1/p-1
SMILES Code
O=C([O-])C1=C(I)C(NC(C)=O)=C(I)C(C(NC)=O)=C1I.[Na+]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
635.90
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Iothalamate. 2018 Oct 31. PMID: 30000465.
2: Seegmiller JC, Burns BE, Schinstock CA, Lieske JC, Larson TS. Discordance Between Iothalamate and Iohexol Urinary Clearances. Am J Kidney Dis. 2016 Jan;67(1):49-55. doi: 10.1053/j.ajkd.2015.08.020. Epub 2015 Oct 9. PMID: 26454686.
3: Sterner G, Bäck SE, Nyman U. Iohexol Versus Iothalamate for GFR Measurement. Am J Kidney Dis. 2016 Jun;67(6):991. doi: 10.1053/j.ajkd.2015.12.035. PMID: 27211370.
4: Delanaye P, Jouret F, Le Goff C, Cavalier E. Concordance Between Iothalamate and Iohexol Plasma Clearance. Am J Kidney Dis. 2016 Aug;68(2):329-330. doi: 10.1053/j.ajkd.2016.01.007. Epub 2016 Feb 3. PMID: 26851202.
5: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Iothalamate Sodium I 125. 2019 Jun 30. PMID: 29999765.
6: Van Houcke SK, Seaux L, Cavalier E, Speeckaert MM, Dumoulin E, Lecocq E, Delanghe JR. Determination of iohexol and iothalamate in serum and urine by capillary electrophoresis. Electrophoresis. 2016 Sep;37(17-18):2363-7. doi: 10.1002/elps.201600084. Epub 2016 Jul 4. PMID: 27279351.
7: Shah I, Barker J, Naughton DP, Barton SJ, Ashraf SS. HPLC estimation of iothalamate to measure glomerular filtration rate in humans. Chem Cent J. 2016 Dec 12;10:80. doi: 10.1186/s13065-016-0227-3. PMID: 28028385; PMCID: PMC5151096.
8: Capuano V, Quintiliani M, Sapora O, Simone G. Radiation chemical and physical mechanisms of radiosensitization of single cell systems by iothalamate. Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Sep;50(3):481-90. doi: 10.1080/09553008614550891. PMID: 3528013.
9: Larson TS, Seegmiller J. In Reply to 'Iohexol Versus Iothalamate for GFR Measurement'. Am J Kidney Dis. 2016 Jun;67(6):991-2. doi: 10.1053/j.ajkd.2016.02.055. PMID: 27211371.
10: Seegmiller JC, Burns BE, Fauq AH, Mukhtar N, Lieske JC, Larson TS. Iothalamate quantification by tandem mass spectrometry to measure glomerular filtration rate. Clin Chem. 2010 Apr;56(4):568-74. doi: 10.1373/clinchem.2009.133751. Epub 2010 Feb 18. PMID: 20167698.
