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MedKoo Cat#: 532842 | Name: TP-680

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TP-680 is a new cholecystokininA receptor antagonist.

Chemical Structure

TP-680
TP-680
CAS#176915-07-4

Theoretical Analysis

MedKoo Cat#: 532842

Name: TP-680

CAS#: 176915-07-4

Chemical Formula: C35H33N5O4S

Exact Mass: 619.2253

Molecular Weight: 619.74

Elemental Analysis: C, 67.83; H, 5.37; N, 11.30; O, 10.33; S, 5.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TP-680; TP 680; TP680.
IUPAC/Chemical Name
2-[(2R)-3-[4-[di(phenyl)methyl]piperazin-1-yl]-2-(1H-indole-2-carbonylamino)-3-oxopropyl]sulfanylpyridine-3-carboxylic acid
InChi Key
InChi Code
InChI=1S/C35H33N5O4S/c41-32(29-22-26-14-7-8-16-28(26)37-29)38-30(23-45-33-27(35(43)44)15-9-17-36-33)34(42)40-20-18-39(19-21-40)31(24-10-3-1-4-11-24)25-12-5-2-6-13-25/h1-17,22,30-31,37H,18-21,23H2,(H,38,41)(H,43,44)/t30-/m0/s1
SMILES Code
O=C(C1=CC=CN=C1SC[C@H](NC(C(N2)=CC3=C2C=CC=C3)=O)C(N4CCN(C(C5=CC=CC=C5)C6=CC=CC=C6)CC4)=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 619.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tachibana I, Kanagawa K, Yamamoto Y, Otsuki M. Pharmacological profile of a new serine derivative cholecystokinin receptor antagonist TP-680 on pancreatic, biliary and gastric function. J Pharmacol Exp Ther. 1996 Dec;279(3):1404-12. PubMed PMID: 8968365. 2: Akiyama T, Tachibana I, Hirohata Y, Shirohara H, Yamamoto M, Otsuki M. Pharmacological profile of TP-680, a new cholecystokininA receptor antagonist. Br J Pharmacol. 1996 Apr;117(7):1558-64. PubMed PMID: 8730754; PubMed Central PMCID: PMC1909435.

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