Related CAS #
111659-76-8
Synonym
Clentiazem maleate; (S,S)-Clentiazem maleate; TA 3090; TA-3090
IUPAC/Chemical Name
(2S,3S)-8-chloro-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate maleate
InChi Key
FTUXVMVEKYLKGE-WECFPGDBSA-N
InChi Code
InChI=1S/C22H25ClN2O4S.C4H4O4/c1-14(26)29-20-21(15-5-8-17(28-4)9-6-15)30-19-13-16(23)7-10-18(19)25(22(20)27)12-11-24(2)3;5-3(6)1-2-4(7)8/h5-10,13,20-21H,11-12H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t20-,21+;/m1./s1
SMILES Code
CC(O[C@](C(N(C1=C(S2)C=C(Cl)C=C1)CCN(C)C)=O)([H])[C@]2([H])C3=CC=C(OC)C=C3)=O.O=C(O)/C([H])=C([H])\C(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
565.03
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Endothelium-dependent calcium-induced relaxation in the presence of Ca2+-antagonists in canine depolarized coronary arteries. K. Kikkawa, S. Murata, T. Nagao Br J Pharmacol. 1989 Oct; 98(2): 700–706. doi: 10.1111/j.1476-5381.1989.tb12645.x PMCID: PMC1854722
2: First‐line drugs inhibiting the renin angiotensin system versus other first‐line antihypertensive drug classes for hypertension Yu Jie Chen, Liang Jin Li, Wen Lu Tang, Jia Yang Song, Ru Qiu, Qian Li, Hao Xue, James M Wright
Cochrane Database Syst Rev. 2018 Nov; 2018(11): CD008170. Published online 2018 Nov 14. doi: 10.1002/14651858.CD008170.pub3 PMCID: PMC6516995
3: Blood pressure targets for hypertension in older adults Scott R Garrison, Michael R Kolber, Christina S Korownyk, Rita K McCracken, Balraj S Heran, G Michael Allan Cochrane Database Syst Rev. 2017 Aug; 2017(8): CD011575. Published online 2017 Aug 8. doi: 10.1002/14651858.CD011575.pub2 PMCID: PMC6483478
4: First‐line drugs for hypertension James M Wright, Vijaya M Musini, Rupam Gill, Cochrane Hypertension Group Cochrane Database Syst Rev. 2018 Apr; 2018(4): CD001841. Published online 2018 Apr 18. doi: 10.1002/14651858.CD001841.pub3 PMCID: PMC6513559
5: Pharmacotherapy for hypertension in adults aged 18 to 59 years Vijaya M Musini, Francois Gueyffier, Lorri Puil, Douglas M Salzwedel, James M Wright Cochrane Database Syst Rev. 2017 Aug; 2017(8): CD008276. Published online 2017 Aug 16. doi: 10.1002/14651858.CD008276.pub2 PMCID: PMC6483466
6: First‐line combination therapy versus first‐line monotherapy for primary hypertension Javier Garjón, Luis Carlos Saiz, Ana Azparren, José J Elizondo, Idoia Gaminde, Mª José Ariz, Juan Erviti Cochrane Database Syst Rev. 2017 Jan; 2017(1): CD010316. Published online 2017 Jan 13. doi: 10.1002/14651858.CD010316.pub2Update in: Cochrane Database Syst Rev. 2020 Feb; 2020(2): CD010316.
PMCID: PMC6464906
