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MedKoo Cat#: 534580 | Name: Monorden diacetate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Monorden diacetate a Hsp90 Inhibitor. Monorden diacetate is a Promising Lead Compound for the Development of Novel Fungicides.

Chemical Structure

Monorden diacetate
Monorden diacetate
CAS#100262-15-5

Theoretical Analysis

MedKoo Cat#: 534580

Name: Monorden diacetate

CAS#: 100262-15-5

Chemical Formula: C22H21ClO8

Exact Mass: 448.0925

Molecular Weight: 448.85

Elemental Analysis: C, 58.87; H, 4.72; Cl, 7.90; O, 28.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
12772-57-5 100262-15-5
Synonym
Monorden diacetate
IUPAC/Chemical Name
6H-Oxireno(E)(2)benzoxacyclotetradecin-6,12(7H)-dione, 9,11-bis(acetyloxy)-8-chloro-1a,14,15,15a-tetrahydro-14-methyl-
InChi Key
IKKGJIXZKBEWBG-YDFGWWAZSA-N
InChi Code
InChI=1S/C22H21ClO8/c1-11-8-17-16(31-17)7-5-4-6-14(26)9-15-20(22(27)28-11)18(29-12(2)24)10-19(21(15)23)30-13(3)25/h4-7,10-11,16-17H,8-9H2,1-3H3/b6-4+,7-5+
SMILES Code
O=C(CC1=C(Cl)C(OC(C)=O)=CC(OC(C)=O)=C12)/C=C/C=C/C3C(O3)CC(C)OC2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 448.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Carcinogenesis. 2017 Oct 1;38(10):1011-1020. doi: 10.1093/carcin/bgx077. PMID: 28968651. 11: Yang Q, Puhm F, Freissmuth M, Nanoff C. Hyponatremia and V2 vasopressin receptor upregulation: a result of HSP90 inhibition. Cancer Chemother Pharmacol. 2017 Oct;80(4):673-684. doi: 10.1007/s00280-017-3390-x. Epub 2017 Aug 4. PMID: 28779264; PMCID: PMC5608778. 12: Alam Q, Alam MZ, Sait KHW, Anfinan N, Noorwali AW, Kamal MA, Khan MSA, Haque A. Translational Shift of HSP90 as a Novel Therapeutic Target from Cancer to Neurodegenerative Disorders: An Emerging Trend in the Cure of Alzheimer's and Parkinson's Diseases. Curr Drug Metab. 2017;18(9):868-876. doi: 10.2174/1389200218666170728115606. PMID: 28758577. 13: Xu L, Wu P, Xue J, Molnar I, Wei X. Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. J Nat Prod. 2017 Aug 25;80(8):2215-2223. doi: 10.1021/acs.jnatprod.7b00066. Epub 2017 Jul 27. PMID: 28749671; PMCID: PMC5819736. 14: Bartsch K, Hombach-Barrigah A, Clos J. Hsp90 inhibitors radicicol and geldanamycin have opposing effects on Leishmania Aha1-dependent proliferation. Cell Stress Chaperones. 2017 Sep;22(5):729-742. doi: 10.1007/s12192-017-0800-2. Epub 2017 Apr 28. PMID: 28455612; PMCID: PMC5573691. 15: Schaletzki Y, Kromrey ML, Bröderdorf S, Hammer E, Grube M, Hagen P, Sucic S, Freissmuth M, Völker U, Greinacher A, Rauch BH, Kroemer HK, Jedlitschky G. Several adaptor proteins promote intracellular localisation of the transporter MRP4/ABCC4 in platelets and haematopoietic cells. Thromb Haemost. 2017 Jan 5;117(1):105-115. doi: 10.1160/TH16-01-0045. Epub 2016 Oct 20. PMID: 27761583. 16: Krzemień-Ojak Ł, Góral A, Joachimiak E, Filipek A, Fabczak H. Interaction of a Novel Chaperone PhLP2A With the Heat Shock Protein Hsp90. J Cell Biochem. 2017 Feb;118(2):420-429. doi: 10.1002/jcb.25669. Epub 2016 Oct 17. 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