SKF-104557, also known as N-Despropyl ropinirole, is an active metabolite of the dopamine D2 receptor agonist ropinirole. SKF-104557 increases extracellular acidification rates in CHO cells expressing human dopamine D2, D3, and D4 receptors (EC50s = 0.63, 0.063, and 1.23 µM, respectively). N-Despropyl ropinirole is also a potential impurity found in commercial preparations of ropinirole.
MedKoo Cat#: 534577
Name: SKF-104557
CAS#: 106916-16-9
Chemical Formula: C13H18N2O
Exact Mass: 218.1419
Molecular Weight: 218.30
Elemental Analysis: C, 71.53; H, 8.31; N, 12.83; O, 7.33
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| DMF | 25.0 | 114.52 | ||
| DMSO | 30.0 | 137.43 | ||
| DMSO:PBS (pH 7.2) (1:4) | 0.2 | 0.92 | ||
| Ethanol | 1.0 | 4.58 |
The following data is based on the product molecular weight 218.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
