SKF-107457 | CAS#126333-28-6 | HIV protease inhibitor

MedKoo Cat#: 598105 | Name: SKF-107457

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SKF-107457 is a HIV protease type 1 inhibitor, and are hexapeptide substrate analogues with the scissile bond being replaced by a hydroxyethylene isostere.

Chemical Structure

SKF-107457

CAS#126333-28-6

Theoretical Analysis

MedKoo Cat#: 598105

Name: SKF-107457

CAS#: 126333-28-6

Chemical Formula: C28H45N5O7

Exact Mass: 563.3319

Molecular Weight: 563.69

Elemental Analysis: C, 59.66; H, 8.05; N, 12.42; O, 19.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SKF-107457; SKF 107457; SKF107457; Ala-Ala-Phepsi(CH(OH)CH2)Gly-Val-Val-OCH3;

IUPAC/Chemical Name

phenyl ((2S)-4-((S)-2-((S)-2-aminopropanamido)propanamido)-2-hexanamido-3-(hydroxymethyl)butanoyl)-L-valinate

InChi Key

GLDYPYOVILJGHJ-FNKAFAPSSA-N

InChi Code

InChI=1S/C28H45N5O7/c1-6-7-9-14-22(35)32-24(20(16-34)15-30-26(37)19(5)31-25(36)18(4)29)27(38)33-23(17(2)3)28(39)40-21-12-10-8-11-13-21/h8,10-13,17-20,23-24,34H,6-7,9,14-16,29H2,1-5H3,(H,30,37)(H,31,36)(H,32,35)(H,33,38)/t18-,19-,20?,23-,24-/m0/s1

SMILES Code

CC(C)[C@@H](C(OC1=CC=CC=C1)=O)NC([C@H](C(CNC([C@H](C)NC([C@H](C)N)=O)=O)CO)NC(CCCCC)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 563.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Murthy KH, Winborne EL, Minnich MD, Culp JS, Debouck C. The crystal structures at 2.2-A resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations. J Biol Chem. 1992 Nov 15;267(32):22770-8. PubMed PMID: 1429626. 2: Wood SJ, Wetzel R. A novel method for the incorporation of glycoprotein-derived oligosaccharides into neoglycopeptides. Bioconjug Chem. 1992 Sep-Oct;3(5):391-6. PubMed PMID: 1420438. 3: Zhao B, Winborne E, Minnich MD, Culp JS, Debouck C, Abdel-Meguid SS. Three-dimensional structure of a simian immunodeficiency virus protease/inhibitor complex. Implications for the design of human immunodeficiency virus type 1 and 2 protease inhibitors. Biochemistry. 1993 Dec 7;32(48):13054-60. PubMed PMID: 8241159. 4: Verkhivker GM. Empirical free energy calculations of human immunodeficiency virus type 1 protease crystallographic complexes. II. Knowledge-based ligand-protein interaction potentials applied to thermodynamic analysis of hydrophobic mutations. Pac Symp Biocomput. 1996:638-52. PubMed PMID: 9390264.