MedKoo Cat#: 593201 | Name: SRI-35241

Description:

WARNING: This product is for research use only, not for human or veterinary use.

​SRI-35241 is a synthetic peptide inhibitor that targets the activation of transforming growth factor-beta (TGF-β) by thrombospondin 1 (THBS1), effectively acting as both a TGF-β inhibitor and a THBS1 antagonist. Its molecular formula is C₁₁H₂₂N₄O₃, with a molecular weight of 258.32 g/mol. Developed by the Southern Research Institute, SRI-35241 has been investigated in preclinical studies for potential therapeutic applications in fibrosis and neoplasms.

Chemical Structure

SRI-35241
CAS#2307429-54-3

Theoretical Analysis

MedKoo Cat#: 593201

Name: SRI-35241

CAS#: 2307429-54-3

Chemical Formula: C11H22N4O3

Exact Mass: 258.1692

Molecular Weight: 258.32

Elemental Analysis: C, 51.15; H, 8.58; N, 21.69; O, 18.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SRI35241; SRI-35241; SRI 35241
IUPAC/Chemical Name
(S)-2-acetamido-5-amino-N-(1-amino-2-methyl-1-oxopropan-2-yl)pentanamide
InChi Key
XBCYIRCOIWJBTN-QMMMGPOBSA-N
InChi Code
InChI=1S/C11H22N4O3/c1-7(16)14-8(5-4-6-12)9(17)15-11(2,3)10(13)18/h8H,4-6,12H2,1-3H3,(H2,13,18)(H,14,16)(H,15,17)/t8-/m0/s1
SMILES Code
CC(N[C@@H](CCCN)C(NC(C)(C)C(N)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 258.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mark J. Suto, Vandana Gupta, Bini Mathew, Wei Zhang, Manuel A. Pallero, Joanne E. Murphy-Ullrich. Identification of Inhibitors of Thrombospondin 1 Activation of TGF-β. J Med Chem. 2020 May 7. https://doi.org/10.1021/acsmedchemlett.9b00540.